TRP Ion Channel Stable Cell Lines

Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins that detect and integrate a variety of physical and chemical stimuli. Mammals express a total of 28 different TRP channel proteins, which can be divided into 7 subfamilies based on amino acid sequence homology: TRPA (Ankyrin), TRPC (Canonical), TRPM (Melastatin), TRPML (Mucolipin), TRPN (NO-mechano-potential, NOMP), TRPP (polycystin), TRPV (vanillic acid). They are a class of ion channels found in a variety of tissues and cell types and are permeable to a variety of cations such as Ca²⁺, Mg²⁺, Na⁺, K⁺, etc.

Figure 1. Distribution of TRP channels in the human body. (Zhang M, et al., 2023)

TRP channels are cellular sensors of a wide range of physical and chemical stimuli. They are involved in the development of vision, hearing, touch, smell, taste, temperature and pain. TRP channels are also extremely sensitive to basic cell signaling components as well as beneficial or harmful environmental inputs. Activation of TRP channels changes membrane potential, allows important signaling ions to cross the cell membrane, changes enzyme activity, initiates endocytosis/exocytosis, etc. It follows that TRP channels play crucial roles in many fundamental processes of life, such as fertilization, sensory transduction, cell survival, and development. Their interactions with numerous physiological signaling pathways and the unique crystal structure of TRP channels make TRPs attractive drug targets and involve them in the treatment of a variety of diseases.

Our TRP Ion Channel Stable Cell Lines

Drawing on decades of experience in cell line engineering and drug discovery, Creative Biogene has accessioned a large collection of cell lines that stably express high levels of TRP ion channels. These TRP ion channel stable cell lines have excellent in vitro assay sensitivity and reproducibility. This cell line enables the assessment of ion channel function by detecting electrophysiological signals. Following ligand/agonist-induced channel activation, responses can be detected by automated or manual electrophysiology techniques.

Application of TRP Ion Channel Stable Cell Lines

Study TRP ion channel gene functions
Investigate cell signaling pathways and signal transduction
Studying the pathogenesis and treatment of channelopathy diseases
High-throughput drug screening

Key Features of Our TRP Ion Channel Stable Cell Lines

Exogenous fragments can be stably expressed in dividing cells for a long time.
Establishing stable cell lines helps to select appropriate numbers of cells for experimental research.
Our TRP ion channel stable cell lines have been rigorously tested and validated.
The target gene can be stably inherited for more than 25 generations.
Our TRP ion channel stable cell lines yield exceptional in vitro assay sensitivity and reproducibility.

Please browse our TRP ion channel stable cell lines collection to find your desired one.

TRP Ion Channel Stable Cell Line List

Cat.No.	Product Name	Price
CSC-RI0056	Human TRPA1 Stable Cell Line-HEK293	Inquiry
CSC-RI0057	Human TRPV1 Stable Cell Line-HEK293	Inquiry
CSC-RI0058	Human TRPV3 Stable Cell Line-HEK293	Inquiry
CSC-RI0191	Human TRPA1 Stable Cell Line-CHO	Inquiry
CSC-RI0193	Human TRPC1 Stable Cell Line-HEK293	Inquiry
CSC-RI0194	Human TRPC6 Stable Cell Line-HEK293	Inquiry
CSC-RI0196	Human TRPM4 Stable Cell Line-CHO	Inquiry
CSC-RI0198	Human TRPM4 Stable Cell Line-HEK293	Inquiry
CSC-RI0199	Human TRPM8 Stable Cell Line-CHO	Inquiry
CSC-RI0203	Human TRPV4 Stable Cell Line-CHO	Inquiry
CSC-RI0204	Human TRPV6 Stable Cell Line-HEK293	Inquiry
CSC-RI0205	Human TRPV6 Stable Cell Line - CHO-K1	Inquiry
CSC-RI0207	Mouse TRPV1 Stable Cell Line - HEK293	Inquiry
CSC-SC011839-1	Human PKD2L1 Stable Cell Line - CHO-K1	Inquiry

* For research use only. Not intended for any clinical use.

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