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Human SCN5A Stable Cell Line-HEK293

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Cat.No.
CSC-RI0051
Background
Nav1.5 is expressed in cardiac myocytes and involved with action potential initiation and conduction. Mutations of Nav1.5 result in QT prolongation and ventricular fibrillation. This ion channel is a target for anti-arrhythmic drugs and the toxic side effects of local anaesthetics.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
SCN5A
Synonyms
SCN5A; sodium channel, voltage-gated, type V, alpha subunit; CMD1E, sodium channel, voltage gated, type V, alpha (long QT syndrome 3); sodium channel protein type 5 subunit alpha; CDCD2; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; long QT syndrome 3; LQT3; Nav1.5; PFHB1; SSS1; voltage-gated sodium channel subunit alpha Nav1.5; sodium channel protein cardiac muscle subunit alpha; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; VF1; CMD1E;
Gene ID
MIM
UniProt ID
Q14524
Chromosome Location
3p21
Pathway
Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosystem; SIDS Susceptibility Pathways, organism-specific biosystem;
Function
calmodulin binding; ion channel activity; protein binding; voltage-gated ion channel activity; voltage-gated sodium channel activity;

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