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Dengue virus infection is a major global health problem, infecting an estimated 50-100 million people each year. With no vaccine or antiviral therapy available, Dengue virus (DENV) causes a variety of clinical outcomes ranging from asymptomatic infection to undifferentiated fever, classic dengue fever (DF) or dengue hemorrhagic fever/dengue shock syndrome (DHS/DSS). DENV belongs to the Flavivirus genus of the Flaviviridae family of enveloped viruses. Flaviviruses are small (about 50 nm), enveloped, single-stranded positive-sense RNA viruses. Their genomes range in size from 10.5 to 11 kb and consist of a single open reading frame (ORF) flanked by 5' and 3' untranslated regions (UTRs) of approximately 100 nucleotides and 500 nucleotides respectively that form specific secondary structures required for genome replication and protein translation. Translation of ORFs results in the synthesis of polyproteins that are cleaved by host and viral proteases to release structural and nonstructural viral proteins.
Infectious DNA clones have been obtained and used to study important viral properties such as virulence/attenuation, cell penetration, replication, host range, and the function of coding or non-coding genomic regions. DENV ORF clones are important tools for genetic analysis of viral replication and pathogenesis, drug design, and vaccine development. DENV ORF clones play a key role in revealing the complex ecology, behavior, and biology of DENV. The situation is further complicated by the fact that four distinct serotypes of dengue virus exist, and infection with one serotype does not confer immunity against the others. DENV ORF clones allow researchers to study each serotype individually in a laboratory setting and understand the unique characteristics of each serotype.
Combining unique and versatile cloning technologies, Creative Biogene has created a large number of high-quality DENV ORF clones. Premade ORF clones eliminate the initial cloning and validation procedures for gene discovery studies. There is no need to perform tedious RNA isolation, cDNA synthesis, cloning, sequencing, and validation procedures steps. Constructive manipulation of DENV ORF clones has accelerated research on all fronts—from understanding virus-host relationships to investigating potential vaccines and antiviral medications. DENV ORF clones have been effectively used to study the pathogenicity and virulence of different DENV serotypes.
Please browse our collection of DENV cDNA clones to find the one you want.
| Cat.No. | Product Name | Price |
|---|---|---|
| CDCB156810 | DENV DENV-NS5A ORF clone (AF038403.1) | Inquiry |
| CDCB156811 | DENV DENV-NS4B ORF clone (AF038403.1) | Inquiry |
| CDCB156812 | DENV DENV-NS4A ORF clone (AF038403.1) | Inquiry |
| CDCB156813 | DENV DENV-NS2A ORF clone (AF038403.1) | Inquiry |
| CDCB156814 | DENV DENV-NS1 ORF clone (AF038403.1) | Inquiry |
| CDCB156815 | DENV DENV-C ORF clone (AF038403.1) | Inquiry |
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