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Hepatitis C virus (HCV), a positive-strand RNA virus of the Flaviviridae family Hepacivirus, is an important blood-borne pathogen. HCV infects an estimated 2% to 3% of the world's population and is the leading cause of hepatitis, cirrhosis, and hepatocellular carcinoma. The genome consists of 5' and 3' untranslated regions (UTRs) and a single open reading frame (ORF), encoding structural proteins (Core, E1, and E2), p7, and nonstructural proteins (NS2, NS3, NS4A, NS4B, NS5A, and NS5B). HCV RNA is approximately 9600 nucleotides (nt) long and encodes a large polyprotein within a single ORF of approximately 3010 amino acids (aa). In the viral genome, the HCV ORF is preceded by a 341 nt 5' UTR, which is highly conserved among viral isolates and serves as an internal ribosome entry site to direct translation of the HCV polyprotein.
Because the different HCV genotypes differ in their biology and susceptibility to therapeutic and neutralizing antibodies, it is important to create research tools for all major genotypes. Therefore, it is necessary to have functional cDNA clones representing major HCV genotypes and important subtypes. HCV ORF clones are critical to understanding the viral life cycle. They provide a clear picture of how viruses enter host cells, replicate, assemble and eventually release their viral progeny. This is crucial for the development of antiviral drugs, as researchers can clearly identify potential targets for therapeutic intervention.
Combining unique and versatile cloning technologies, Creative Biogene has created a large number of high-quality HCV ORF clones. Premade ORF clones eliminate the initial cloning and validation procedures for gene discovery studies. There is no need to perform tedious RNA isolation, cDNA synthesis, cloning, sequencing, and validation procedures steps. The use of HCV ORF clones has enabled the research community to better understand the role of certain HCV proteins in viral replication. For example, studies using ORF clones have identified clear roles for HCV proteins such as NS5A in viral replication and pathogenesis, thereby identifying them as potential targets for antiviral therapy.
Please browse our collection of HCV cDNA clones to find the one you want.
| Cat.No. | Product Name | Price |
|---|---|---|
| CDCB156804 | HCV HCV-NS5A ORF clone (NC_004102.1) | Inquiry |
| CDCB156843 | HCV HCV-Core ORF clone (AB047639.1) | Inquiry |
| CDCB156802 | HCV HCV-NS2/3 ORF clone (NC_004102.1) | Inquiry |
| CDCB156803 | HCV HCV-NS5B ORF clone (NC_004102.1) | Inquiry |
| CDCB156805 | HCV HCV-NS4B ORF clone (NC_004102.1) | Inquiry |
| CDCB156806 | HCV HCV-NS4A ORF clone (NC_004102.1) | Inquiry |
| CDCB156807 | HCV HCV-P7 ORF clone (NC_004102.1) | Inquiry |
| CDCB156808 | HCV HCV-E2 ORF clone (NC_004102.1) | Inquiry |
| CDCB156809 | HCV HCV-E1 ORF clone (NC_004102.1) | Inquiry |
| CDCB156839 | HCV HCV-Core ORF clone (D49374.1) | Inquiry |
| CDCB156840 | HCV HCV-Core ORF clone (GU814263.1) | Inquiry |
| CDCB156841 | HCV HCV-Core ORF clone (D50409.1) | Inquiry |
| CDCB156842 | HCV HCV-Core ORF clone (D10988.1) | Inquiry |
| CDCB156844 | HCV HCV-Core ORF clone (D14853.1) | Inquiry |
| CDCB156845 | HCV HCV-Core ORF clone (AF054250.1) | Inquiry |
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