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Calcium channels are transmembrane ion channels permeable to calcium ions. Once inside the cell, Ca2+ activates specific calcium receptor proteins such as calmodulin, troponin-C, or calcium-activated calcium, potassium, and chloride channels. These channels are the primary pathway for calcium translocation across the plasma membrane of excitable cells and serve to support a variety of functions including muscle contraction, hormone and neurotransmitter release, cell motility, cell growth and regulation, cell damage and death, and finally cell survival. Calcium channels can be gated by voltage or ligand binding. Voltage-gated calcium channels are opened by depolarization membrane potentials, allowing the influx of calcium ions from outside the cell. There are five types of voltage-gated calcium channels: L-type, P-type, N-type, R-type and T-type. Ligand-gated calcium channels are opened by the binding of a ligand, such as a neurotransmitter to the receptor. Types of ligand-gated calcium channels include IP3 receptors, ryanodine receptors, and two-pore channels.
Figure 1. Diagram of voltage-gated calcium channel subunit topology. (Zamponi G W, et al. 2015)
Calcium channels are important regulators of brain, heart, and muscle function, and their dysfunction can cause pathophysiological conditions ranging from cardiovascular disease to neurological and psychiatric disorders such as epilepsy, pain, and autism. Calcium channels have been recognized as therapeutic targets for the treatment of a variety of diseases. Calcium channel blockers, also called calcium channel antagonists, block the flow of calcium ions through the channels. Calcium channel antagonists block the inward movement of calcium by binding to L-type "long-acting" voltage-gated calcium channels in the heart, vascular smooth muscle, and pancreas. In the nervous system, calcium channel blockers have been successfully used to treat absence seizures and are emerging as potential therapeutic avenues for treating conditions such as pain, addiction, Parkinson's disease, and anxiety. Cardiovascular indications include hypertension, angina, supraventricular arrhythmias, coronary spasm, hypertrophic cardiomyopathy, and pulmonary hypertension.
Transfected stable cell lines are important research tools for drug discovery, compound screening, and gene therapy research. Based on many years of experience in cell line development, Creative Biogene has accessioned a large collection of calcium channel cell lines to aid in the study of calcium channels. These calcium channel stable cell lines have excellent in vitro assay sensitivity and reproducibility. They enable the assessment of ion channel function by detecting electrophysiological signals.
Please browse our calcium channel stable cell lines collection to find your desired one.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RI0001 | Human CACNA1B Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0002 | Human CACNA1H Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0067 | Human CACNA1C/CACNB2/CACNA2D1 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0068 | Human CACNA1C/CACNB2/CACNA2D1 Stable Cell Line-CHO | Inquiry |
| CSC-RI0071 | Human CACNA1A/CACNB4/CACNA2D1 Stable Cell Line-CHO | Inquiry |
| CSC-RI0075 | Human CACNA1B/CACNB3/CACNA2D1 Stable Cell Line-CHO | Inquiry |
| CSC-RI0077 | Human CACNA1G Stable Cell Line-HEK293 | Inquiry |
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