Human SCNN1A/SCNN1B/SCNN1G Stable Cell Line-CHO-K1

Name: Human SCNN1A/SCNN1B/SCNN1G Stable Cell Line-CHO-K1
SKU: CSC-RI0086
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0086

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

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Gene Information

Cat. No.	CSC-RI0086
Description	This cell line is engineered to overexpress human SCNN1G
Background	The human SCNN1A, B and G genes encode the heteromeric ENaC channel, a constitutively active, amiloride-sensitive Na+-selective ion channel. ENaC expressed in kidney and colon is a therapeutic target in hypertension, congestive heart disease and inflammatory bowel disease.
Target Gene	SCNN1G
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuSCNN1A/SCNN1B/SCNN1G
Alias	SCNN1G, PHA1, BESC3, ENaCg
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	SCNN1G sodium channel, non-voltage-gated 1, gamma subunit [ Homo sapiens ]
Gene Symbol	SCNN1G
Synonyms	SCNN1G; sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, non voltage gated 1, gamma , sodium channel, nonvoltage gated 1, gamma; amiloride-sensitive sodium channel subunit gamma; ENaCgamma; SCNEG; gamma-ENaC; gamma-NaCH; ENaC gamma subunit; epithelial Na(+) channel subunit gamma; sodium channel, nonvoltage-gated 1, gamma; nonvoltage-gated sodium channel 1 subunit gamma; amiloride-sensitive sodium channel gamma-subunit; amiloride-sensitive epithelial sodium channel gamma subunit; PHA1; BESC3; ENaCg;
GeneID	6340
Uni ProtID	P51170
mRNA Refseq	BC059391
Chromosome Location	16p12
Function	WW domain binding; ion channel activity; ligand-gated sodium channel activity; protein binding; sodium channel activity;
Pathway	Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Taste transduction, organism-specific biosystem; Taste transduction, conserved biosystem;
MIM	600761

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