Human SCN2A Stable Cell Line-CHO-K1

Name: Human SCN2A Stable Cell Line-CHO-K1
SKU: CSC-RI0048
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0048

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0048
Description	This cell line is engineered to overexpress human SCN2A.
Background	The voltage gated sodium channel isoform Nav1.2 is involved with axon potential initiation and conduction. Nav1.2 is the target of antiepileptic drugs and the probable target causing side effects of centrally active local anaesthetics. It is detected in relative abundance on myelin-deficient areas on axons in the central and peripheral nervous systems. Demyelinated axons expressing Nav1.2 are much less susceptible to axonal degeneration. The action of a drug on Nav1.2 sodium channels may interfere with the fine balance between axon growth and nerve impulse transmission.
Target Gene	SCN2A
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuSCN2A
Alias	SCN2A, BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	SCN2A sodium channel, voltage-gated, type II, alpha subunit [ Homo sapiens ]
Gene Symbol	SCN2A
Synonyms	HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2
Gene Description	sodium channel, voltage-gated, type II, alpha subunit
Gene ID	6326
Uni Prot ID	Q99250
m RNA Refseq	NM_001040143.1
Protein Refseq	NP_001035233.1
Chromosome Location	2q24.3
Function	voltage-gated sodium channel activity;
Pathway	Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosystem;
MIM	182390

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