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Human SCN2A Stable Cell Line-CHO

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Cat.No.
CSC-RI0048
Background
The voltage gated sodium channel isoform Nav1.2 is involved with axon potential initiation and conduction. Nav1.2 is the target of antiepileptic drugs and the probable target causing side effects of centrally active local anaesthetics. It is detected in relative abundance on myelin-deficient areas on axons in the central and peripheral nervous systems. Demyelinated axons expressing Nav1.2 are much less susceptible to axonal degeneration. The action of a drug on Nav1.2 sodium channels may interfere with the fine balance between axon growth and nerve impulse transmission.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
SCN2A
Synonyms
HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2; sodium channel protein type 2 subunit alpha; sodium channel protein type 2 subunit alpha; HBSC II; voltage-gated sodium channel subtype II; sodium channel protein type II subunit alpha; sodium channel protein brain II subunit alpha; voltage-gated sodium channel subunit alpha Nav1.2; sodium channel protein, brain type 2 alpha subunit; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide
Gene ID
MIM
UniProt ID
Q99250
Chromosome Location
2q24.3
Pathway
Axon guidance; Developmental Biology; Interaction between L1 and Ankyrins; L1CAM interactions; Apoptotic process; Myelination; Sodium ion transport
Function
Voltage-gated sodium channel activity

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