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Cat.No. : CSC-RI0048 Host Cell: CHO-K1
| Cat. No. | CSC-RI0048 |
| Description | This cell line is engineered to overexpress human SCN2A. |
| Background | The voltage gated sodium channel isoform Nav1.2 is involved with axon potential initiation and conduction. Nav1.2 is the target of antiepileptic drugs and the probable target causing side effects of centrally active local anaesthetics. It is detected in relative abundance on myelin-deficient areas on axons in the central and peripheral nervous systems. Demyelinated axons expressing Nav1.2 are much less susceptible to axonal degeneration. The action of a drug on Nav1.2 sodium channels may interfere with the fine balance between axon growth and nerve impulse transmission. |
| Gene | SCN2A |
| Gene Species | Homo sapiens (Human) |
| Alias | SCN2A, BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2 |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
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