Human SCN1A Stable Cell Line-CHO

Name: Human SCN1A Stable Cell Line-CHO
SKU: CSC-RI0154
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0154

Host Cell : CHO Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0154
Description	This cell line is engineered to overexpress human SCN1A.
Background	The human SCN1A gene encodes the pore-forming subunit of Nav1.1, a voltage-gated sodium channel expressed in CNS neurons and dorsal root ganglia. Mutations in SCN1A cause several types of epilepsies (generalized epilepsy with febrile seizures, severe myoclonic epilepsy in infancy) and some forms of familial hemiplegic migraine. Nav1.1 channels are therapeutic targets in seizure, stroke, and pain.
Target Gene	SCN1A
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuSCN1A
Alias	SCN1A, EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEI
Host Cell	CHO
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	SCN1A sodium channel, voltage-gated, type I, alpha subunit [ Homo sapiens ]
Gene Symbol	SCN1A
Synonyms	FEB3; FHM3; NAC1; SCN1; SMEI; EIEE6; FEB3A; HBSCI; GEFSP2; Nav1.1
Gene Description	sodium channel, voltage-gated, type I, alpha subunit
GeneID	6323
Uni ProtID	P35498
mRNA Refseq	NM_006920.4
Protein Refseq	NP_008851.3
Chromosome Location	2q24.3
Function	voltage-gated sodium channel activity;
Pathway	Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosystem;
MIM	182389

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