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Human SCN1A Stable Cell Line-CHO

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Cat.No.
CSC-RI0154
Background
The human SCN1A gene encodes the pore-forming subunit of Nav1.1, a voltage-gated sodium channel expressed in CNS neurons and dorsal root ganglia. Mutations in SCN1A cause several types of epilepsies (generalized epilepsy with febrile seizures, severe myoclonic epilepsy in infancy) and some forms of familial hemiplegic migraine. Nav1.1 channels are therapeutic targets in seizure, stroke, and pain.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO
Ship
Dry ice
Gene Information
Official Symbol
SCN1A
Synonyms
SCN1A; EIEE6; FEB3; FEB3A; FHM3; GEFSP2; HBSCI; NAC1; Nav1.1; SCN1; SMEI; sodium channel, voltage-gated, type I, alpha subunit; sodium channel protein brain I subunit alpha; sodium channel protein type 1 subunit alpha; sodium channel protein type I subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel voltage gated type 1 alpha subunit; sodium channel, voltage-gated, type I, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.1; voltage-gated sodium channel type I
Gene ID
MIM
UniProt ID
P35498
Chromosome Location
2q24.3
Pathway
Axon guidance; Developmental Biology; Dopaminergic synapse; Interaction between L1 and Ankyrins; L1CAM interactions
Function
sodium ion binding; voltage-gated sodium channel activity

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