Human SCN8A Stable Cell Line-CHO

Name: Human SCN8A Stable Cell Line-CHO
SKU: CSC-RI0168
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0168

Host Cell : CHO Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0168
Description	This cell line is engineered to overexpress human SCN8A.
Background	The human SCN8A gene encodes the pore-forming subunit of Nav1.6, a voltage-gated sodium channel expressed in central and peripheral nervous systems. Mutations in the mouse ortholog cause ataxia and other movement disorders. Nav1.6 channels are therapeutic targets in multiple sclerosis and seizure.
Target Gene	SCN8A
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuSCN8A
Alias	SCN8A, CerIII, NaCh6, Nav1.6, PN4, MED, CIAT, CERIII, EIEE13, FLJ33996
Host Cell	CHO
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	SCN8A sodium channel, voltage gated, type VIII, alpha subunit [ Homo sapiens ]
Gene Symbol	SCN8A
Synonyms	MED; PN4; CIAT; NaCh6; CERIII; EIEE13; Nav1.6
GeneID	6334
Uni ProtID	Q9UQD0
mRNA Refseq	NM_001177984.2
Protein Refseq	NP_001171455.1
Chromosome Location	12q13
Function	ATP binding; voltage-gated sodium channel activity; voltage-gated sodium channel activity;
Pathway	Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosystem;
MIM	600702

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