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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are a family of six-transmembrane domain, single-pore ring, hyperpolarization-activated, nonselective cation channels. HCN ion channels are voltage-activated and ligand-activated membrane proteins that contribute to the electrical excitability and pacemaking activity of cardiac and neuronal cells. These channels are members of the voltage-gated Kv channel superfamily and the cyclic nucleotide-binding domain subfamily of ion channels. HCN channels are unique among vertebrate voltage-gated ion channels in that they have reverse voltage dependence, resulting in activation upon hyperpolarization. There are four isoforms of HCN: HCN1, 2, 3, and 4, which differ in their biophysical properties and expression levels in the heart and central nervous system. HCN1 is the fastest activating form, while HCN4 is the slowest activating form. The C-terminus of the channel contains a cyclic nucleotide-binding domain, where cyclic nucleotides confer its regulatory role.
HCN channels are involved in diverse neuronal processes, including sensory signal transduction, synaptic plasticity, dendritic integration, pacemaking and network oscillations, motor learning, etc., making them likely contributors to pathological behaviors when defective. Growing evidence supports the notion that alterations in HCN physiological functions contribute to the pathogenic mechanisms underlying certain neurological diseases in humans, such as epilepsy, pain, and Parkinson's disease (PD). Therefore, HCN channels have long been considered attractive therapeutic targets. There is evidence that inhibiting HCN channel function results in disruption of electrical signaling. Therefore, blocking HCN channels can have an analgesic effect and reduce pain. For example, the nonselective HCN channel blocker ZD-7288 inhibits mechanical and thermal hypersensitivity in different neuropathic pain models.
Transfected stable cell lines are important research tools for drug discovery, compound screening, and gene therapy research. Based on many years of experience in cell line development, Creative Biogene has accessioned a large collection of HCN channel cell lines to aid in the study of HCN channels. These HCN stable cell lines have excellent in vitro assay sensitivity and reproducibility. They enable the assessment of HCN channel function by detecting electrophysiological signals.
Please browse our HCN channel stable cell lines collection to find your desired one.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RI0011 | Human HCN1 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0012 | Human HCN2 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0013 | Human HCN3 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0014 | Human HCN4 Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0099 | Human HCN1 Stable Cell Line-HEK293, tetracycline-inducible | Inquiry |
| CSC-RI0100 | Human HCN2 Stable Cell Line-CHO | Inquiry |
| CSC-RI0102 | Human HCN4 Stable Cell Line-HEK293 | Inquiry |
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