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Human SCN9A Stable Cell Line-HEK293

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Cat.No.
CSC-RI0053
Background
Nav1.7 is a voltage-gated sodium channel alpha subunit. It is expressed in all types of DRG neurons, sympathetic neurons, Schwann cells and neuroendocrine cells. This channel is involved in action potential initiation and transmission in peripheral neurons and is a potential target for local anaesthetic agents. Specific hereditary mutations in the gene encoding Nav1.7, SCN9A, result in the painful neuropathies, erythermalgia and paroxysmal extreme pain disorder, that can be ascribed to altered firing of pain sensing neurons. Changes in the expression levels of the channel correlates with increases in neuronal excitability in acute and chronic pain syndromes. Hence due to their relatively discrete location and fundamental role in mediating certain types of pain they may be promising targets for pharmacological intervention.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
SCN9A
Synonyms
SCN9A; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage gated, type IX, alpha polypeptide; sodium channel protein type 9 subunit alpha; ETHA; Nav1.7; NE NA; NENA; PN1; hNE-Na; peripheral sodium channel 1; neuroendocrine sodium channel; sodium channel protein type IX subunit alpha; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel subunit alpha Nav1.7; sodium channel, voltage-gated, type IX, alpha polypeptide; SFNP; FEB3B; NE-NA; GEFSP7;
Gene ID
MIM
UniProt ID
Q15858
Chromosome Location
2q24
Pathway
Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosystem;
Function
voltage-gated ion channel activity; voltage-gated sodium channel activity;

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