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Chloride channels belong to the ion channel superfamily and allow anions (mainly chloride ions) to pass passively across cell membranes. Chloride channels are involved in a variety of biological processes, including the regulation of neuronal, skeletal, cardiac, and smooth muscle excitability, cell volume regulation, transepithelial salt transport, and acidification of intracellular and extracellular compartments. All known Cl- channels can be classified into voltage-sensitive ClC subfamily, transmitter-gated GABAA and glycine receptors, calcium-activated Cl- channels (such as TMEM16A), high (maxi) conductance Cl- channels, the cystic fibrosis transmembrane conductance regulator (CFTR), and volume-regulated channels.
Figure 1. Localization of chloride intracellular channel proteins. (Gururaja Rao S, et al. 2020)
Given that chloride channels are involved in a wide range of biological functions, it is not difficult to imagine that they will play a role in the diagnosis, prognosis, and treatment of a variety of human physiological and pathological conditions. Chloride channel has been shown to play critical roles in cardiovascular, pulmonary, neurological and auditory functions as well as various malignancies. Levels and expression of chloride channels may be used as diagnostic and prognostic markers in these diseases. In addition, mutations in several chloride channels cause human diseases, including cystic fibrosis, kidney stones, macular degeneration, myotonia, renal salt wasting, and excessive convulsions. Chloride channel modulators have potential applications in the treatment of some of these diseases, as well as secretory diarrhea, polycystic kidney disease, osteoporosis, and hypertension. GABAA (gamma-aminobutyric acid A) receptor chloride channel modulators have been put into clinical use, and several small molecule chloride channel modulators are in preclinical development and clinical trials.
Transfected stable cell lines are important research tools for drug discovery, compound screening, and gene therapy research. Based on many years of experience in cell line development, Creative Biogene has accessioned a large collection of chloride channel cell lines to aid in the study of chloride channels. These chloride channel stable cell lines have excellent in vitro assay sensitivity and reproducibility. They enable the assessment of ion channel function by detecting electrophysiological signals.
Please browse our chloride channel stable cell lines collection to find your desired one.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RI0003 | Human CFTR Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0004 | Human GABRA1 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0005 | Human GABRA2 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0006 | Human GABRA3 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0007 | Human GABRA4 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0008 | Human GABRA5 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0009 | Human GABRA6 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0010 | Human GLRA1 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0081 | Human CFTR Stable Cell Line-CHO | Inquiry |
| CSC-RI0082 | Human CLCN1 Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0084 | Human CLCN2 Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0087 | Human GABRA3/GABRB2/GABRG2 Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0088 | Human GABRA1/GABRB2/GABRG2 Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0089 | Human GABRA2/GABR2/GABRG2 Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0090 | Human GABRA5/GABRB2/GABRG2 Stable Cell Line-CHO-K1 | Inquiry |
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