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Human SCN8A Stable Cell Line-HEK293

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Cat.No.
CSC-RI0052
Background
Nav1.6 is primarily expressed in the output neurones of the cerebellum, cortex and hippocampus of the CNS and in the Nodes of Ranvier of sensory and motor axons of the PNS. Nav1.6 is involved with the initiation and transmission of action potentials in central neurons and their myelinated axons. Mutation or disruption of the Nav1.6 gene causes cerebellar ataxia and motor end plate disease in mice. This channel is a potential target for analgesic and antiepileptic drugs.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
SCN8A
Synonyms
SCN8A; sodium channel, voltage gated, type VIII, alpha subunit; MED, sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel protein type 8 subunit alpha; CerIII; NaCh6; Nav1.6; PN4; hNa6/Scn8a voltage-gated sodium channel; voltage-gated sodium channel subunit alpha Nav1.6; MED; CIAT; CERIII; EIEE13; FLJ33996;
Gene ID
MIM
UniProt ID
Q9UQD0
Chromosome Location
12q13.1
Pathway
Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosystem;
Function
ATP binding; nucleotide binding; voltage-gated ion channel activity; voltage-gated sodium channel activity; voltage-gated sodium channel activity;

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