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West Nile virus (WNV) is a neurotropic mosquito-borne pathogen belonging to the Flavivirus genus within the Flaviviridae family. WNV can cause illness ranging from mild fever to more serious illness such as encephalitis or meningitis. WNV is spread by mosquitoes. In rare cases, the virus can spread in transfused blood, a transplanted organ, or through the placenta to a fetus. WNV is an enveloped, single-stranded, positive-sense RNA virus approximately 11 kb in size. The sequenced genome contained 10,982 nucleotides encoding a polyprotein of 3,434 amino acids in a single open reading frame. This polyprotein consists of three structural proteins (C, prM/M, and E) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5).
Open reading frames (ORFs) are genes that have been identified as key building blocks of proteins. ORF cloning of WNV offers researchers a unique opportunity to better understand the virus, discovering how each protein produced by the virus affects virulence and immune evasion. With the help of ORF cloning, we can expand our understanding of the biology of this virus in host systems, identify key viral genes that contribute to its pathogenesis, and generally assist in the development of pharmacological interventions.
Combining unique and versatile cloning technologies, Creative Biogene has created a large number of high-quality WNV ORF clones. Premade ORF clones eliminate the initial cloning and validation procedures for gene discovery studies. There is no need to perform tedious RNA isolation, cDNA synthesis, cloning, sequencing, and validation procedures steps. A major advantage of using ORF cloning in WNV research is its ability to decipher the role of individual genes in viral replication and pathogenicity. This allows researchers to alter the virus's genetic material in a controlled laboratory setting, testing what each gene does and the consequences of its absence.
Please browse our collection of WNV cDNA clones to find the one you want.
| Cat.No. | Product Name | Price |
|---|---|---|
| CDCB156800 | WNV WNV-prM and E ORF clone (DQ211652.1) | Inquiry |
| CDCB156801 | WNV WNV-C ORF clone (DQ211652.1) | Inquiry |
| CDCB156953 | WNV WNV-NS5 ORF clone (DQ211652.1) | Inquiry |
| CDCB156954 | WNV WNV-NS3 ORF clone (DQ211652.1) | Inquiry |
| CDCB156955 | WNV WNV-NS1 ORF clone (DQ211652.1) | Inquiry |
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