Ligand-gated Ion Channel Stable Cell Lines

Ligand-gated ion channels (LICs, LGICs), also commonly known as ionotropic receptors, are a group of transmembrane ion channel proteins that open to allow Na⁺, K⁺, Ca²⁺ and/or Cl⁻ plasma to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand) (such as a neurotransmitter). LGICs are integral membrane proteins containing a pore that regulates the flow of selected ions across the plasma membrane. The ion flux is passive and driven by the electrochemical gradient of permeating ions. Channels are opened, or gated, by binding of neurotransmitters to positive sites, triggering conformational changes that result in conduction states. The LGIC superfamily includes excitatory, nicotinic acetylcholine, cation-selective, ionotropic glutamate, 5-HT3, and P2X receptors and inhibitory, anion-selective, GABAA, and glycine receptors.

LGICs are activated upon binding of neurotransmitters to the ion channel and are involved in rapid synaptic transmission in the nervous system. Many LGICs have widespread tissue distribution outside the nervous system and have functions beyond synaptic transmission. These channels play important roles in signal transduction in neurons and cardiomyocytes. Because ion channel receptors are involved in neuronal death induced by excitatory glutamate stimulation, there has been considerable interest in these receptors as therapeutic targets for the treatment of brain diseases involving neuronal death, such as ischemic stroke. Interactions between ionotropic glutamate receptors and other proteins, such as GluR2-GAPDH and NR2-PSD-95, can enhance cell survival after ischemic injury and thus represent an approach to neuroprotective treatments after stroke.

Our Ligand-gated Ion Channel Stable Cell Lines

Transfected stable cell lines are important research tools for drug discovery, compound screening, and gene therapy research. Based on many years of experience in cell line development, Creative Biogene has accessioned a large collection of cell lines that stably express high levels of ligand-gated ion channels. These ligand-gated ion channel stable cell lines can be used for screening ion channel inhibitors. They enable the assessment of ion channel function by detecting electrophysiological signals.

Application of Ligand-gated Ion Channel Stable Cell Lines

Study LGICs gene functions
Screen for activators or inhibitors of LGICs
Applicable for manual and automated patch-clamp studies
Study the pathogenesis and treatment of channelopathy diseases

Key Features of Our Ligand-gated Ion Channel Stable Cell Lines

These included cell lines overexpress LGICs.
Our LGIC stable cell lines have been rigorously tested and validated.
Proprietary cell line vector technologies for optimum stability, expression, and uniform current
The target gene can be stably inherited for more than 25 generations.
These LGIC cell lines have been screened to confirm the absence of Mycoplasma species.
Our LGIC stable cell lines yield exceptional in vitro assay sensitivity and reproducibility.

Please browse our ligand-gated ion channel stable cell lines collection to find your desired one.

Ligand-gated Ion Channel Stable Cell Line List

Cat.No.	Product Name	Price
CSC-RI0004	Human GABRA1 Stable Cell Line-HEK293	Inquiry
CSC-RI0005	Human GABRA2 Stable Cell Line-HEK293	Inquiry
CSC-RI0006	Human GABRA3 Stable Cell Line-HEK293	Inquiry
CSC-RI0007	Human GABRA4 Stable Cell Line-HEK293	Inquiry
CSC-RI0008	Human GABRA5 Stable Cell Line-HEK293	Inquiry
CSC-RI0009	Human GABRA6 Stable Cell Line-HEK293	Inquiry
CSC-RI0010	Human GLRA1 Stable Cell Line-HEK293	Inquiry
CSC-RI0015	Human ASIC3 Stable Cell Line-HEK293	Inquiry
CSC-RI0016	Human GRIK2 Stable Cell Line-HEK293	Inquiry
CSC-RI0017	Human CHRNA1 Stable Cell Line-HEK293	Inquiry
CSC-RI0018	Human CHRNA3 Stable Cell Line-HEK293	Inquiry
CSC-RI0019	Human CHRNA2 Stable Cell Line-HEK293	Inquiry
CSC-RI0020	Human CHRNA7 Stable Cell Line-HEK293	Inquiry
CSC-RI0059	Human HTR3A Stable Cell Line-HEK293	Inquiry
CSC-RI0061	Human CHRNA3/CHRNB4 Stable Cell Line-CHO-K1	Inquiry

* For research use only. Not intended for any clinical use.

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