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Human SCN10A Stable Cell Line-HEK293

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Cat.No.
CSC-RI0054
Background
Nav1.8 is a voltage-gated sodium channel alpha subunit. It is expressed in mammalian adult dorsal root ganglion (DRG) neurons, predominantly those with small diameter cell bodies that give rise to the unmyelinated (C-type) fibres. These fibres form synapses in the dorsal horn of the spinal cord and are mainly involved in pain signaling. This channel conducts the characteristic slow, tetrodotoxin-resistant (TTX-r) currents involved in action potential initiation and transmission in these neurons and is therefore a potential target for analgesic agents. Altered expression of Nav1.8 is observed in pain models and human pain states-channel protein can be seen to re-localise from cell bodies to the site of insult or injury. There is also good evidence from antisense oligonucleotide studies for a role in development of hyperexciteable states in pain models. However KO mice show surprisingly limited pain phenotypes, possibly due to compensatory up-regulation of other Nav subtypes. Native sodium channels are multi-subunit complexes, composed of not only the pore forming alpha subunit, but also auxiliary beta subunits. The beta1 subunit is known to increase peak current amplitude as well as increasing sodium ion channel expression at the cell surface.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
SCN10A
Synonyms
SCN10A; sodium channel, voltage-gated, type X, alpha subunit; sodium channel, voltage gated, type X, alpha polypeptide; sodium channel protein type 10 subunit alpha; hPN3; Nav1.8; PN3; SNS; peripheral nerve sodium channel 3; sodium channel protein type X subunit alpha; voltage-gated sodium channel subunit alpha Nav1.8; sodium channel, voltage-gated, type X, alpha polypeptide;
Gene ID
MIM
UniProt ID
Q9Y5Y9
Chromosome Location
3p22.2
Function
voltage-gated ion channel activity; voltage-gated sodium channel activity;

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