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As the causative agent of AIDS, human immunodeficiency virus (HIV) poses a threat to global public health and economy. The HIV pandemic is characterized by extensive genomic diversity caused by multiple factors, including multiple zoonotic transmissions into the human population, high viral evolution and recombination rates. HIV isolates are currently divided into two types: HIV type 1 (HIV-1) and HIV type 2 (HIV-2). The worldwide main agent of AIDS is HIV-1, while HIV-2 is restricted to some regions of Western and Central Africa.
HIV-1 consists of two noncovalently linked, unspliced, positive-sense single-stranded RNA copies. Both copies of the RNA strand are essential for HIV-1 recombination, which occurs during reverse transcription of viral replication. The virion contains two copies of single-stranded RNA, but only a single DNA provirus is produced, called a pseudodiploid. The RNA component is 9749 nucleotides long, has a 5' cap (Gppp), a 3' poly(A) tail, and numerous open reading frames (ORFs). Viral structural proteins are encoded by long ORFs, while smaller ORFs encode regulators of the viral life cycle: attachment, membrane fusion, replication, and assembly.
Combining unique and versatile cloning technologies, Creative Biogene has created a large number of high-quality HIV ORF clones. Premade ORF clones eliminate the initial cloning and validation procedures for gene discovery studies. There is no need to perform tedious RNA isolation, cDNA synthesis, cloning, sequencing, and validation procedures steps. These HIV ORF clones allow researchers to study individual viral proteins in isolation, allowing a detailed understanding of their structure and function. Additionally, HIV ORF clones can help create a detailed map of viral gene function and how they interact with host cell machinery. The knowledge gained can guide researchers in identifying potential targets for HIV treatment or prevention strategies.
Please browse our collection of HIV cDNA clones to find the one you want.
| Cat.No. | Product Name | Price |
|---|---|---|
| CDCB156956 | HIV GP125 ORF clone (AB731740.1) | Inquiry |
| CDCB156957 | HIV HIV-gag ORF clone (AB731740.1) | Inquiry |
| CDCB156958 | HIV HIV-env ORF clone (GU111555.1) | Inquiry |
| CDCB156959 | HIV HIV-gag ORF clone (GU111555.1) | Inquiry |
| CDCB156960 | HIV HIV-env ORF clone (AB485666.1) | Inquiry |
| CDCB156961 | HIV HIV-gag ORF clone (AB485666.1) | Inquiry |
| CDCB156962 | HIV HIV-env ORF clone (GQ324962.1) | Inquiry |
| CDCB156963 | HIV HIV-gag ORF clone (GQ324962.1) | Inquiry |
| CDCB156964 | HIV HIV-env ORF clone (M27323.1) | Inquiry |
| CDCB156965 | HIV HIV-gag ORF clone (M27323.1) | Inquiry |
| CDCB156966 | HIV HIV-env ORF clone (U52953.1) | Inquiry |
| CDCB156967 | HIV HIV-gag ORF clone (U52953.1) | Inquiry |
| CDCB156968 | HIV HIV-nef ORF clone (K03455) | Inquiry |
| CDCB156969 | HIV HIV-env ORF clone (K03455) | Inquiry |
| CDCB156970 | HIV HIV-rev ORF clone (K03455) | Inquiry |
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