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Human GABRA1 Stable Cell Line-HEK293

See other products for GABRA1
Cat.No.
CSC-RI0004
Background
GABA is the major inhibitory neurotransmitter in the CNS, binding to fast-acting ionotropic GABAA receptors to cause inward flux of Cl-resulting in membrane hyperpolarization and thus reducing membrane excitability. Excessive stimulation of these receptors can lead to sedation and ataxia whereas attenuation leads to arousal, insomnia and anxiety. Since modulation of these receptors has such profound physiological effects they have become important drug targets for the treatment of many conditions e.g. anxiety, epilepsy, sleep disorders and for anesthesia. GABAA receptors are pentameric structures typically consisting of alpha, beta and gamma2 subunits in a stoichiometry of 2:2:1. The specific subunit composition is especially important since various combinations mediate different effects. For example, alpha1-containing receptors, accounting for 60% of all GABAA receptors, mediate the sedative/hypnotic effects of benzodiazepines (BZPs) whereas the anxiolytic effects of these drugs are mediated by receptors containing alpha2 and alpha3 subunits. Hence, developing selective allosteric modulators for these latter subunits should ultimately lead to anxiolytic drugs devoid of unwanted sedative effects.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
GABRA1
Synonyms
GABRA1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1; EJM5; GABA(A) receptor; alpha 1; GABA(A) receptor, alpha 1; GABA(A) receptor subunit alpha-1; EJM; ECA4;
Gene ID
MIM
UniProt ID
P14867
Chromosome Location
5q34
Pathway
GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem;
Function
GABA-A receptor activity; chloride channel activity; drug binding; extracellular ligand-gated ion channel activity; ion channel activity; receptor activity;
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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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