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Human ASIC3 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0015
Background
Acid-sensing ion channels (ASICs) are structurally related to epithelial sodium channel proteins. They are gated by protons, blocked by amiloride, and their transcripts are localized to sensory ganglia. Their pH sensitivity and distribution makes them interesting candidates to serve as primary transducers of local pH changes during ischemia or tissue injury to pain signals to the CNS. These channels can allow quite large and persistent inward currents in native sensory neurons that can cause sustained firing of action potentials that lead to pain perception. Using the rat ASIC3 sequence de Weille et al. cloned the human gene encoding ASIC3. During severe cardiac ischemia extracellular pH levels can drop as low as 6.7, and a study of eight different functional properties of large acid-gated currents in rat cardiac afferent neurons corresponded well to ASIC3 channels transfected into COS-7 cells.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
ASIC3
Synonyms
ACCN3; TNaC1; DRASIC; SLNAC1; acid-sensing ion channel 3; acid-sensing ion channel 3; testis sodium channel 1; modulatory subunit of ASIC2a; proton-gated cation channel subunit; amiloride-sensitive cation channel 3, testis; neuronal amiloride-sensitive cation channel 3
Gene ID
MIM
UniProt ID
Q9UHC3
Chromosome Location
7q35
Pathway
Sensory perception; Signal transduction; Sodium ion transmembrane transport; Transport
Function
Cation channel activity; Ligand-gated sodium channel activity; Sodium channel activity

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