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Human GRIK2 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0016
Background
GluR6 is a member of the ligand-gated, kainate family of glutamate receptors also known as GRIK2. It can form both hetero and homo-tetrameric, cation permeable, channels and is expressed at high levels in the hippocampus and striatum of the CNS. Pre- and postsynaptic kainate receptors are able to regulate both neurotransmitter release and excitability in a synapse-specific manner. GRIK2 has been implicated in a range of neurophysiological conditions such as autism, obsessive compulsive disorder, as well as disease states e.g. Schizophrenia, epilepsy and Huntingdon’s disease.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
GRIK2
Synonyms
GRIK2; glutamate receptor, ionotropic, kainate 2; GLUR6; glutamate receptor, ionotropic kainate 2; GluK2; MRT6; gluR-6; bA487F5.1; glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; excitatory amino acid receptor 4; EAA4; GLR6; GLUK6; MGC74427;
Gene ID
MIM
UniProt ID
Q13002
Chromosome Location
6q16.3
Pathway
Activation of Ca-permeable Kainate Receptor, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Activation of Na-permeable Kainate Receptors, organism-specific biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem; Ionotropic activity of Kainate Receptors, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
PDZ domain binding; extracellular-glutamate-gated ion channel activity; ion channel activity; kainate selective glutamate receptor activity; protein homodimerization activity; receptor activity; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding;

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