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Human GABRA4 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0007
Background
Gamma-aminobutyric acid (GABA)-gated ion channels are widely distributed in the mammalian brain and are major mediators of inhibitory synaptic transmission. A typical GABA ion channel has a pentameric structure consisting of 5 protein subunits, often alpha, beta and gamma or delta, combining to form a central ion conducting pore across the cell membrane. In humans there are six genes that encode alpha subunits, three that encode beta, three that encode gamma, and an additional seven genes that encode other subunits whose function is less-well understood than the alpha, beta and gamma subunits. GABA ion channels open and close in response to secretion of GABA from presynaptic terminals. GABAA alpha4 channels comprised of alpha4, beta3, and gamma2 subunits are extrasynaptic, estimated to represent<5% of="" all="" gabaa="" receptors="" located="" in="" the="" brain,="" and="" insensitive="" to="" benzodiazepines.="" research="" interest="" has="" focused="" on="" alpha4-containing="" receptors="" because="" they="" are="" potentiated="" by="" concentrations="" of="" ethanol="" experienced="" by="" human="" drinkers="" (1-3="" mm);="" one="" study="" showed="" this="" effect="" requires="" the="" delta="" subunit="" is="" part="" of="" the="">
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
GABRA4
Synonyms
GABRA4; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor; alpha 4; GABA(A) receptor, alpha 4;
Gene ID
MIM
UniProt ID
P48169
Chromosome Location
4p12
Pathway
GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem;
Function
GABA-A receptor activity; benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; ion channel activity; receptor activity;

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