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Cat.No. : CSC-RI0061 Host Cell: CHO-K1
| Cat. No. | CSC-RI0061 |
| Description | This cell line is engineered to overexpress human CHRNB4. |
| Background | Nicotinic receptors (nAChR) are acetylcholine-activated non-selective cation channels that mediate excitatory neurotransmission. The receptor-channels are configured as hetero- or homopentamers. The human CHRNA3 and CHRNB4 genes encode a cationic-selective, ionotropic alpha3/beta 4 nicotinic acetylcholine receptor (nAChR). Channels that contain a3 subunits typically have lower Ca2+ permeability compared to those containing a7 subunits. Therefore, alpha7 nAChRs are particularly important in regulation of Ca2+-dependent signalling pathways. Tissue distribution also differs with alpha3/beta 4 receptors prominent in autonomic ganglia and alpha7 receptors widely distributed in the CNS. |
| Gene | CHRNB4 |
| Gene Species | Homo sapiens (Human) |
| Alias | CHRNB4 |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
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