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Cat.No. : CSC-RI0081 Host Cell: CHO
| Cat. No. | CSC-RI0081 |
| Description | This cell line is engineered to overexpress human CFTR. |
| Background | The human CFTR gene encodes the pore-forming subunit of the cAMP-regulated epithelial chloride channel associated with cystic fibrosis. |
| Gene | CFTR |
| Gene Species | Homo sapiens (Human) |
| Alias | CFTR, ABCC7, CF, ABC35, CFTR/MRP, dJ760C5.1, MRP7, TNR CFTR, CF, ABCC7, TNR-CFTR |
| Host Cell | CHO |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The cell line was constructed by stably transfecting the human CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene into CHO cells, using techniques such as molecular cloning and cell screening.
A: As this cell line stably expresses the human CFTR gene, it can simulate CFTR functions in cystic fibrosis patient cells and is suitable for drug screening and pathological mechanism studies.
A: Attention should be paid to the impact of drugs on CFTR channel functions, including channel opening and closing kinetics and regulation of chloride ion permeability.
A: It can be used to study the function of CFTR in intestinal epithelial cells, especially in research related to digestive system pathology in cystic fibrosis.
A: By strictly controlling experimental conditions including cell density, drug concentration, and timing, as well as replicating experiments to ensure the reliability of results.
A: As CFTR plays a key role in regulating chloride ion and water balance in airway epithelial cells, this cell line can be used for research on cystic fibrosis and other respiratory diseases.
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