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GPCR Stable Cell Lines


Creative Biogene offers GPCR Transfected Stable Cell Lines for your research, please inquiry online.

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GPCR Stable Cell Lines

GPCR (G protein-coupled receptors), are important proteins in cell signaling, with the ability to bind the nucleotides guanosine triphosphate (GTP) and guanosine diphosphate (GDP). GPCR are the largest and most diverse group of membrane receptors in eukaryotes, and play a role in an incredible array of functions in the human body, from sensation to growth to hormone responses. The findings suggest that the topological conformation of GPCR is a seven-transmembrane domain. When the ligand outside the membrane interacts with GPCR, part of the receptor inside the membrane activate a nearby G protein through binding and interaction, and thus initiate different signal transduction pathways, as well as various biological effects.

GPCR Stable Cell Lines

The key point for new drugs research and development is to find, identify and prepare the drug targets. In more than 500 drug targets which have been discovered, GPCR occupy the majority, approximately 50%. Increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third and one-half of all marketed drugs act by binding to GPCR. GPCR have been widely used to screen drugs and study the etiology and pathogenesis of autoimmune diseases. So it’s necessary for researchers to build GPCR stable over-expressing cell lines.

Creative Biogene has professional research team and advanced technological platform, and can provide a series of GPCR over-expressing cell lines to meet all your needs. So far, Creative Biogene has successfully constructed GPCR over-expressing stable cell lines of various species, which has become one of the world's largest banks of GPCR cells. These cell lines have been verified in the functionality and stability through reporter gene assay or intracellular calcium assay, to satisfy our customers’ requirements for screening GPCR-target drugs and final evaluation.

Applications

  • Study the specific interactions between GPCRs and their ligands, to better reveal the mechanism of cell signaling.
  • Construct cell models for high throughput drugs screening to discover the etiology and pathogenesis of autoimmune diseases and provide a solution.

Advantages

  • One-stop service: Customized cell generation project was managed by experienced scientists throughout the process, from construction design to drug screening.
  • Experienced: Creative Biogene has professional research team with experience of many years in the field of molecular and cell biology.
  • Broad cell types: Creative Biogene has successfully constructed GPCR over-expressing stable cell lines with 293, CHO, HeLa, 1321N1, U2OS, RH7777 etc.
  • Genetic stability: Our GPCR over-expressing cell lines have been rigorously tested and validated for at least 10 passages continous culture without significant change in assay window.
  • High Quality: Our GPCR over-expressing cell lines have no mycoplasma contamination.
  • Cost & Time saving: There are a lot of choices for premade GPCR stable cells enabling for long-term screening, and ready-to-assay/division-arrested GPCR cells suitable for small scale screening assays.

Table 1. Frequently Requested - GPCR Stable Cell Lines
(Gene official symbol listed from A to Z, h: human, r: rat)

hADCYAP1R1 hADORA1 hADORA2A hADORA2B hADORA3 hADRA1A hADRA1B hADRA1D
hADRA2A hADRA2B hADRA2C hADRB1 hADRB2 hADRB3 hADRBK2 hAGTR1
hAPLNR hAPLNR hAVPR1A rAvpr1a hAVPR1B hAVPR2 hBDKRB1 hBDKRB2
hBRS3 hC3AR1 hC5AR1 hCALCR hCALCRL hCASR hCCKAR hCCKBR
hCCR1 hCCR10 hCCR2 hCCR3 hCCR4 hCCR5 hCCR6 hCCR7
hCCR8 hCCR9 hCHRM1 hCHRM2 hCHRM3 hCHRM4 hCHRM5 hCMKLR1
hCNR1 hCNR2 hCRHR1 hCRHR2 hCX3CR1 hCXCR1 hCXCR2 hCXCR3
hCXCR4 hCXCR5 hCXCR6 hCYSLTR1 hCYSLTR2 hDRD1 hDRD2 hDRD3
hDRD4 hDRD5 hEDNRA hEDNRB hF2RL1 hFFAR2 hFFAR3 hFPR1
hFPR2 hFSHR hGABBR1 hGALR1 hGALR2 hGCGR hGHRHR hGHSR
hGIPR hGLP1R hGLP2R hGNRH1 hGNRHR hGPBAR1 hGPR119 hGPR39
hGPR68 hGRM1 hGRM2 hGRPR hH3F3A hHCAR2 hHCRTR1 hHCRTR2
hHRH1 hHRH2 hHRH3 hHTR1A hHTR2A hHTR2B hHTR2C hHTR4
hHTR6 hHTR7 hKISS1R hLPAR1 hLPAR2 hLPAR3 hLPAR5 hLTB4R
hMC2R hMC3R hMC4R hMC5R hMCHR1 hMCHR2 hMLNR hMRGPRD
hMRGPRX1 hMRGPRX2 hMTNR1A hNMBR hNMUR1 hNMUR2 hNPBWR1 hNPSR1
hNPY2R hNPY4R hNTSR1 hO3FAR1 hOPRD1 hOPRK1 hOPRL1 hOPRM1
hOXGR1 hOXTR hP2RY1 hP2RY11 hP2RY12 hP2RY2 hP2RY4 hPPYR1
hPRLHR hPROKR1 hPROKR2 hPTAFR hPTGDR hPTGDR2 hPTGER1 hPTGER2
hPTGER3 hPTGER4 hPTGFR hPTGIR hPTH1R hPTH2R hQRFPR hQRFPR
hS1PR1 hS1PR2 hS1PR3 hS1PR4 hS1PR5 hSCTR hSSR2 hSSTR1
hSSTR2 hSSTR3 hSSTR4 hSSTR5 hSUCNR1 hTACR1 hTACR2 hTACR3
hTBXA2R hTRHR hTSHR hUTS2R hVIPR1 hVIPR2 hXCR1  

Table 2. Available For Ready-To-Assay/Division-Arrested GPCR Cells
(Gene official symbol listed from A to Z, h: human, m: mouse, r: rat, d: dog)

hADCYAP1R1 hADORA1 hADORA2A hADORA2B rAdora2b hADORA3 hADRA1A hADRA1B
hADRA1D hADRA2A hADRA2B hADRA2C hADRB1 hADRB2 hADRB3 hADRBK2
hAGTR1 hAPLNR hAPLNR hAVPR1A hAVPR1B hAVPR2 hBDKRB1 hBDKRB2
hBRS3 hC3AR1 hC5AR1 hCALCR hCALCRL hCASR rCasr hCCKAR
hCCKBR hCCR1 hCCR10 hCCR2 hCCR3 hCCR4 hCCR5 hCCR6
mCcr6 hCCR7 hCCR8 hCCR9 mCcr9 dCcr9 rCcr9 hCHRM1
hCHRM2 hCHRM3 hCHRM4 hCHRM5 hCMKLR1 hCNR1 hCNR2 hCRHR1
hCRHR2 hCX3CR1 hCXCR1 hCXCR2 hCXCR3 hCXCR4 hCXCR5 hCXCR6
hCXCR7 hCYSLTR1 hCYSLTR2 hDRD1 hDRD2 hDRD4 hDRD5 hEDNRA
rEdnra hEDNRB hF2R hF2RL1 hFFAR1 rFfar1 mFfar1 hFFAR2
rFfar2 mFfar3 hFFAR3 rFfar3 hFPR1 hFPR2 hFSHR hGABBR1
hGALR1 hGALR2 hGCGR hGHRHR mGhsr hGHSR hGIPR hGLP1R
hGLP2R hGNRH1 hGNRHR rGpbar1 hGPBAR1 mGpbar1 hGPR119 hGPR142
mGpr183 hGPR3 hGPR35 hGPR37L1 hGPR39 hGPR50 hGPR55 hGPR68
hGPR84 hGRM1 hGRM2 hGRM3 rGrm4 hGRM4 mGrm4 hGRM5
hGRM6 hGRM7 hGRM8 hGRPR hH3F3A hHCAR2 hHCAR3 hHCRTR1
hHCRTR2 hHRH1 hHRH2 hHRH3 mHrh3 hHRH4 mHrh4 hHTR1A
hHTR1B dHTR2A hHTR2A hHTR2B hHTR2C hHTR4 hHTR6 hHTR7
rKiss1r hKISS1R hLPAR1 hLPAR2 hLPAR3 hLPAR4 hLPAR5 mLpar5
hLTB4R hLTB4R2 hMC2R hMC4R hMC5R rMchr1 hMCHR1 hMCHR2
hMLNR hMRGPRD hMRGPRX1 hMRGPRX2 hMTNR1A hMTNR1B mMtnr1b rNmbr
hNMBR hNMUR1 hNMUR2 hNPBWR1 rNpbwr1 hNPBWR2 mNpsr1 hNPSR1
hNPY1R hNPY2R rNpy2r hNPY5R hNTSR1 hO3FAR1 rO3far1 mO3far1
rOprd1 hOPRD1 rOprk1 hOPRK1 hOPRL1 rOprl1 rOprm1 hOPRM1
hOXGR1 hOXTR hP2RY1 hP2RY11 rP2ry12 hP2RY12 hP2RY13 hP2RY14
hP2RY2 rP2ry2 hP2RY4 hP2RY6 hPPYR1 hPRLHR hPROKR1 hPROKR2
hPTAFR hPTGDR hPTGDR2 hPTGER1 hPTGER2 hPTGER3 hPTGER4 hPTGFR
hPTGIR hPTH1R hPTH2R hQRFPR hRXFP1 hRXFP3 hS1PR1 hS1PR2
hS1PR3 hS1PR4 hS1PR5 hSCTR hSMO hSSR2 hSSTR1 hSSTR2
hSSTR3 hSSTR4 hSSTR5 hSUCNR1 rTaar1 hTAAR1 hTACR1 hTACR2
hTACR3 hTBXA2R hTRHR rTshr hTSHR hUTS2R rUts2r hVIPR1
hVIPR2 hXCR1            

GPCR Stable Cell Lines Products List