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PV-Mediated Drug Delivery for Tumor Immunotherapy

-The application of PV-based delivery systems in tumor immunotherapy

PV systems are known to be capable of content material delivery to specific host cells through their only round of replication. Therefore, when packaged with 'suicide genes' dictating for tumor cell death, it becomes a powerful weapon against malignancies that could be difficult for conventional drug administration, for example cancers in mucosal tissues. The efficacy of PV-based suicide gene delivery has been demonstrated by research on treatment of bladder cancer. In this application, artificially assembled PVs act as delivery vectors transferring suicide genes to the internal of tumor cells. Successful induction of tumor cell death (TCD) and further adaptive immune response against NIMBC has been achieved on immunotherapy using PV vectors packaged in Human Papillomavirus (HPV) capsids.

PV-Mediated Drug Delivery for Tumor ImmunotherapyFig 1. Mechanisms of PVs delivering their content (Rohovie, Nagasawa, & Swartz, 2016).

-The advantage of PV-mediated systems to conventional approaches?

  1. Capability to effectively deliver therapeutic entities to sites otherwise challenging to reach;
  2. High PV titer;
  3. Capability to induce adaptive immune response against cancer, reducing the risk for recurrence.

-What is offered by Creatvie Biogene?

  1. Establishment of virion transfected cell lines;
  2. Construction of 'suicide gene' bearing PVs associated with reporter gene;
  3. Pre-clinical trials on animal models.

We also offer fully customized solutions should your research requires specific items/services that have not been included. For any inquiries, please feel free to contact us at 1-631-626-9181 or email: , our highly experienced technical support scientists are more than happy to discuss over details of your research plan and offer the best solution catered specifically to your needs.

-Why Creative Biogene?

Creative Biogene has rich history of success and commitment to providing our clients with the best service using only state-of-the-art equipment and finest materials. Coming from world renowned institutions around the globe, researchers of our laboratory team are well-trained and highly experienced with the devotion and dedication to fulfill any requirements by our clients to satisfactory. At Creative Biogene, industry-leading PV customization service is offered to all of our clients at competitive pricing with rapid turnaround time, ensuring an easy and trouble-free start of your research.

Reference:

  1. Rohovie M. J., Nagasawa M. & Swartz R. M., (2016), 'Virus-like particles: next-generation nanoparticles for targeted therapeutic delivery', Bioengineering and Translational Medicine, 2:43-57.
For research use only. Not intended for any clinical use.