Morpholino Oligomers Synthesis Service

Creative Biogene is a leading biotechnology company specializing in the synthesis of morpholino oligomers for customers. With state-of-the-art equipment, advanced technologies, and a highly experienced team, Creative Biogene can offer custom morpholino oligomers at various scales to meet the specific needs of clients. Creative Biogene 's goal is to provide affordable, high-quality synthesis services to ensure your satisfaction in a timely and professional manner.

Fig.1 Structural comparison of DNA and morpholino oligomers.

Morpholino oligomers also known as Phosphorodiamidate morpholino oligomers (PMO), Morpholinos or MO, are a subclass of antisense oligonucleotides (ASOs) that have the canonical nucleic acid backbone replaced by morpholino rings connected by phosphorodiamidate linkages. Morpholino oligomers are single-stranded DNA analogs that have favorable biophysical properties, including high solubility in aqueous solutions, minimal metabolic degradation due to their neutral charge, and robust duplex stability. These characteristics make them promising candidates for therapeutic applications. PMOs have been approved by the US Food and Drug Administration (FDA) for the treatment of Duchenne muscular dystrophy (DMD) since 2016, and they have been designed to target Marburg, Ebola, Picornaviruses, and other viruses, along with bacterial targets and have been developed as anti-cancer agents.

Applications of Morpholino Oligomers:

Antisense Therapy: Morpholino oligomers can be designed to bind to specific mRNA sequences to inhibit the translation of target proteins. This property is utilized in treating genetic disorders by targeting the defective mRNA.
Gene Regulation: Morpholino oligomers can bind to specific mRNA sequences, blocking translation or splicing, thus reducing the expression of targeted genes.
Antiviral Applications: Morpholino oligomers have shown potential in treating viral infections by targeting the viral RNA, thereby hindering the replication of the virus.
Functional Studies: Morpholinos are frequently used in cell culture systems to interrogate the roles of specific genes, validate gene targets, and explore cellular pathways.

Creative Biogene is a leading biotechnology company with extensive experience in providing custom morpholino oligomers tailored to meet your specific needs. Creative Biogene is a reliable partner dedicated to helping you accelerate your research goals. If you have any special requirements for our morpholino oligomers synthesis services, please feel free to contact us. We are looking forward to working together on your attractive projects.

References:

Nan Y and Zhang Y-J (2018) Antisense Phosphorodiamidate Morpholino Oligomers as Novel Antiviral Compounds. Front. Microbiol. 9:750. doi: 10.3389/fmicb.2018.00750.
Gupta S., et al. (2023). Morpholino oligonucleotide-mediated exon skip** for DMD treatment: Past insights, present challenges and future perspectives. Journal of Biosciences, 48(4), 38.

* For research use only. Not intended for any clinical use.

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