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Creative Biogene, one of the leading biotechnology companies, has established comprehensive dsRNA synthesis platform which is available to provide fluorescent-labeled dsRNA synthesis service for global clients. With the help of our highly experienced staffs, Creative Biogene can provide a variety of fluorescent labeling to meet your specific needs. Creative Biogene's goal is to provide you with the most affordable, high-quality fluorescent-labeled dsRNA synthesis service to ensure your satisfaction in a timely and professional manner.
Double -stranded RNA (dsRNA) is an essential molecule in various cellular processes, from eukaryotic organisms to viruses. dsRNA is fundamental to triggering of gene silencing through RNA interference (RNAi) through production of small RNAs (sRNAs), including microRNAs (miRNAs) and small interfering RNAs (siRNAs). In this process, long dsRNA is cleaved into small RNA molecules of 21-23 base pairs (bp) short interfering RNAs (siRNAs) by RNase III type of proteins called Dicers. Subsequently, short RNA duplexes are loaded onto ARGONAUTE (AGO) enzymes and associated proteins that together form the RNA-induced silencing complex (RISC). One strand of the RNA duplex is discarded, while the remaining guide strand guides the RISC to complementary mRNAs through base-pairing resulting in mRNA cleavage and degradation. RNAi has recently become a powerful reverse genetic tool for functional characterization of genes in different model and non-model organisms. Furthermore, this technology is being developed to apply this tool in crop improvement, pest management and therapeutics.
Tracking the introduced dsRNA in live cells is a necessary step to understanding the mechanism of RNAi. Fluorescent labeling is one easy way to localize these macromolecules. Creative Biogene possesses sophisticated equipments, advanced technologies and highly experienced staffs that are available to offer fluorescent-labeled dsRNA synthesis service as cost effectively and quickly as possible, without compromising on quality. If you have any special requirements in our fluorescent-labeled dsRNA synthesis service, please feel free to contact us. We are looking forward to working together with your attractive projects.
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