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CAR Plasmid Preparation Service


Creative Biogene is a biotechnology company specializing in CAR plasmid DNA preparation service.

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CAR Plasmid Preparation Service

Creative Biogene is a biotechnology company specializing in CAR plasmid DNA preparation service. Creative Biogene's sophisticated equipment, advanced technologies and highly experienced staffs are available to provide you with the complete CAR plasmid preparation service, including stable cell bank generation, process development, quality control assay, supporting documentation preparation, etc. Creative Biogene’s goal is to provide you with the most affordable, high-quality CAR plasmid DNA preparation services to ensure your satisfaction in a timely and professional manner.

CAR Plasmid Preparation ServiceFig 1. The four generations of CAR T cells are depicted in a manner that emphasizes the differences in the intracellular domain region of the CAR.[1]

Chimeric antigen receptors (CARs, also known as artificial T cell receptors) are engineered receptors which endowing an immune effector cell (T cell) with an arbitrary specificity via a monoclonal antibody. CAR-T cell therapy refers to a treatment that uses such transformed cells for cancer therapy. It has been shown that CAR T-cell therapy is the most promising approach for cancer therapy for its remarkable ability to eliminate various kinds of tumors. With the in-depth study of CAR-T cell therapy, a large number of CAR plasmid with high quality and purity are needed. As a leading supplier of plasmid preparation service, Creative Biogene’s DNA programs meet manufacturing standards worldwide, with full regulatory support from our Quality Assurance team. With batch sizes from 1 to 100 litres, Creative Biogene can manufacture for clinical through to commercial scale supply with the option of freeze drying / lyophilisation, if required.

Creative Biogene is able to provide the following CAR plasmid DNA preparation service to meet your various needs:

Service Milestone ServiceApplication
GMP IND™ Plasmid Development
  • Gene synthesis and cloning
  • GMP cell bank generation
  • Process development
  • Analytical methods development
  • Pilot manufacture and release
  • Stability study
  • Documentation
Clinical trial application
GMP Grade Plasmid DNA Production
  • 10L batch production
  • 20L batch production
  • 50L batch production
  • 100L batch production
Early clinical trial

Key features of Creative Biogene's CAR plasmid preparation service

  1. One-stop solution: from target DNA sequence to GMP plasmid preparation.
  2. Manufacture process development, including cell pool screening, cell clone screening, culture optimization, purification optimization, etc.
  3. Strict quality control: including cell bank quality control assays and plasmid quality control, etc.
  4. Fast turnaround time.
  5. Cost-saving: provide high quality CAR plasmid with competitive price.

If you have any special requirements in our CAR plasmid preparation service, please feel free to contact us at or 1-631-626-9181. We are looking forward to working together with your attractive projects.

Reference:
  1. Smith, A J., et al. (2016). Chimeric antigen receptor (CAR) T cell therapy for malignant cancers: summary and perspective. Journal of Cellular Immunotherapy, 2(2), 59-68.

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