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DYRK1A


Official Full Name
dual specificity tyrosine phosphorylation regulated kinase 1A
Organism
Homo sapiens
Gene ID
1859
Background
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
Synonyms
MNB; DYRK; HP86; MNBH; MRD7; DYRK1

Cat.No. Product Name Price
SHH020693 shRNA set against Human DYRK1A(NM_101395.2) Inquiry
SHH282265 shRNA set against Human DYRK1A (NM_001396.3) Inquiry
SHH020711 shRNA set against Human DYRK1A(NM_130438.2) Inquiry
SHH020729 shRNA set against Mouse Dyrk1a(NM_007890.2) Inquiry
SHH020747 shRNA set against Human DYRK1A(NM_001396.3) Inquiry
SHH020765 shRNA set against Human DYRK1A(NM_130436.2) Inquiry
SHH282269 shRNA set against Mouse DYRK1A (NM_007890.2) Inquiry
SHH282273 shRNA set against Rat DYRK1A (NM_012791.2) Inquiry
SHW005062 shRNA set against Chicken DYRK1A (NM_204550) Inquiry
Cat.No. Product Name Price
CDCR057994 Human DYRK1A ORF clone (NM_130438.2) Inquiry
CDCR244490 Mouse Dyrk1a ORF Clone(NM_007890.2) Inquiry
CDCR377651 Rat Dyrk1a ORF Clone(NM_012791.2) Inquiry
MiUTR1H-03059 DYRK1A miRNA 3'UTR clone Inquiry
MiUTR1H-03060 DYRK1A miRNA 3'UTR clone Inquiry
MiUTR1H-03061 DYRK1A miRNA 3'UTR clone Inquiry
MiUTR1H-03062 DYRK1A miRNA 3'UTR clone Inquiry
MiUTR1M-04081 DYRK1A miRNA 3'UTR clone Inquiry
CDCB166537 Chicken DYRK1A ORF Clone (NM_204550) Inquiry
CDCB187714 Rabbit DYRK1A ORF clone (XM_008274878.1) Inquiry
CDCR057990 Human DYRK1A ORF clone (NM_101395.2) Inquiry
CDCR057993 Human DYRK1A ORF clone (NM_130436.2) Inquiry
CDCR057996 Human DYRK1A ORF clone (NM_001396.3) Inquiry
CDCR236887 Mouse Dyrk1a ORF Clone(NM_001113389.1) Inquiry
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