Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-DC004084 | Panoply™ Human DCLK1 Knockdown Stable Cell Line | Inquiry |
| CSC-SC004084 | Panoply™ Human DCLK1 Over-expressing Stable Cell Line | Inquiry |
| CLOE-0843 | Human DCLK1(Gly/Pro) Insect Cell Lysate | Inquiry |
| CLOE-0844 | Human DCLK1(His/GST) Insect Cell Lysate | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| AD04638Z | Human DCLK1 adenoviral particles | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| SHG223741 | shRNA set against Mouse Dclk1(NM_019978.3) | Inquiry |
| SHH275169 | shRNA set against Human DCLK1 (NM_004734.4) | Inquiry |
| SHH275173 | shRNA set against Mouse DCLK1 (NM_019978.3) | Inquiry |
| SHH275177 | shRNA set against Rat DCLK1 (NM_053343.3) | Inquiry |
| SHW003545 | shRNA set against Chicken DCLK1 (NM_001257257) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| MiUTR3H-07063 | DCLK1 miRNA 3'UTR clone | Inquiry |
| CDFR013099 | Rat Dclk1 cDNA Clone(NM_053343.3) | Inquiry |
| CDFL003463 | Mouse Dclk1 cDNA Clone(NM_019978.3) | Inquiry |
| CDCH385020 | Rat DCLK1 ORF clone(NM_021584.2) | Inquiry |
| CDCR053888 | Mouse Dclk1 ORF clone (NM_001111053.1) | Inquiry |
| CDCR053890 | Mouse Dclk1 ORF clone (NM_001111052.1) | Inquiry |
| CDFG021702 | Mouse Dclk1 cDNA Clone(NM_001195540.1) | Inquiry |
| CDFG021700 | Mouse Dclk1 cDNA Clone(NM_001195539.1) | Inquiry |
| CDFG021699 | Mouse Dclk1 cDNA Clone(BC133685) | Inquiry |
| CDFG019046 | Mouse Dclk1 cDNA Clone(NM_001111051.1) | Inquiry |
| CDFG019045 | Mouse Dclk1 cDNA Clone(NM_001111053.1) | Inquiry |
| CDFG019042 | Mouse Dclk1 cDNA Clone(NM_001111052.1) | Inquiry |
| MiUTR1M-03712 | DCLK1 miRNA 3'UTR clone | Inquiry |
| CDCR380186 | Rat Dclk1 ORF Clone(NM_053343.3) | Inquiry |
| CDCR243452 | Mouse Dclk1 ORF Clone(NM_001195540.1) | Inquiry |
| CDCR243448 | Mouse Dclk1 ORF Clone(NM_001195538.1) | Inquiry |
| CDCR053904 | Mouse Dclk1 ORF clone (NM_001195539.1) | Inquiry |
| CDCR053900 | Human DCLK1 ORF clone (NM_001195415.1) | Inquiry |
| CDCR053898 | Human DCLK1 ORF clone (NM_001195416.1) | Inquiry |
| CDCR053896 | Human DCLK1 ORF clone (NM_001195430.1) | Inquiry |
| CDCR053892 | Mouse Dclk1 ORF clone (NM_001111051.1) | Inquiry |
| CDCH385011 | Human DCLK1 ORF clone(NM_004734.4) | Inquiry |
| CDCB193675 | Rabbit DCLK1 ORF clone (XM_008273545.1) | Inquiry |
| CDCR254604 | Mouse Dclk1 ORF Clone(NM_019978.3) | Inquiry |
| CDCB165020 | Chicken DCLK1 ORF Clone (NM_001257257) | Inquiry |
Doublecortin-like kinase 1 (DCLK1) is an evolutionarily conserved serine/threonine kinase that shares homology with the Xenopus laevis doublecortin protein (DCX), which is involved in brain development and neuronal migration. DCLK1 has been implicated in various cellular processes, including cell fate determination, neuronal migration, axon guidance, and synaptic plasticity.
The DCLK1 gene is encoded by 21 exons and spans approximately 300 kb on chromosome 10q22.3. The protein consists of 561 amino acids and exhibits a modular structure, with several conserved domains. The N-terminal region contains a pleckstrin homology (PH) domain, followed by a doublecortin domain (DCX) and a calmodulin-binding domain (CaM-BD). The central region includes a kinase domain, while the C-terminal region contains a PDZ domain and a leucine-rich repeat (LRR) motif.
DCLK1 is involved in diverse signaling pathways and plays a crucial role in cellular processes such as cell migration, proliferation, and survival. The PH domain mediates the interaction of DCLK1 with phospholipid-rich membranes, promoting cell migration and invasion. The DCX domain interacts with microtubules and is responsible for the regulation of neuronal migration. The CaM-BD domain enables the interaction of DCLK1 with calmodulin, which modulates the kinase activity and cellular localization of the protein.
Figure 1. DCLK1 as a direct IKKβ regulator in inflammatory signaling.
The kinase domain of DCLK1 phosphorylates various substrates, including proteins involved in cell adhesion, cytoskeletal organization, and transcription factors. The phosphorylation of these substrates influences their activity and cellular function, leading to changes in cell behavior. The PDZ domain interacts with the C-terminal region of target proteins and is responsible for the localization of DCLK1 to specific cellular compartments. The LRR motif is involved in protein-protein interactions and plays a role in the recruitment of DCLK1 to sites of neuronal synapse formation.
DCLK1 is highly expressed during embryonic development and is involved in the formation and differentiation of the nervous system. In the adult central nervous system (CNS), DCLK1 is expressed in various neuronal subtypes and plays a role in synaptic plasticity and neuronal repair. Abnormal expression or function of DCLK1 has been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy.
In addition to its role in neurodevelopment and function, DCLK1 has been implicated in cancer development and progression. Overexpression of DCLK1 has been observed in various cancer types, including breast, colon, and glioblastoma, and is associated with increased cell proliferation, migration, and invasion. Furthermore, DCLK1 has been identified as a potential therapeutic target for the treatment of cancer and other diseases.
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