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MAP3K3


Official Full Name
mitogen-activated protein kinase kinase kinase 3
Organism
Homo sapiens
Gene ID
4215
Background
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Synonyms
CCM5; MEKK3; MAPKKK3

Cat.No. Product Name Price
SHH174107 shRNA set against Human MAP3K3(NM_002401.3) Inquiry
SHH174125 shRNA set against Human MAP3K3(NM_203351.1) Inquiry
SHH174143 shRNA set against Mouse Map3k3(NM_011947.3) Inquiry
SHH337699 shRNA set against Human MAP3K3 (NM_002401.3) Inquiry
SHH337703 shRNA set against Mouse MAP3K3 (NM_011947.3) Inquiry
SHH337707 shRNA set against Rat MAP3K3 (NM_001107058.2) Inquiry
Cat.No. Product Name Price
CDFG013482 Human MAP3K3 cDNA Clone(NM_203351.1) Inquiry
CDFH010988 Human MAP3K3 cDNA Clone(NM_002401.3) Inquiry
CDFH010989 Human MAP3K3 cDNA Clone(NM_002401.3) Inquiry
MiUTR1H-06060 MAP3K3 miRNA 3'UTR clone Inquiry
MiUTR1H-06061 MAP3K3 miRNA 3'UTR clone Inquiry
MiUTR1M-06919 MAP3K3 miRNA 3'UTR clone Inquiry
SKO0582 MAP3K3 Validated sgRNA vector Inquiry
CDCB184742 Rabbit MAP3K3 ORF clone (XM_008271691.1) Inquiry
CDCL130243 Mouse MAP3K3 ORF clone (NM_203351.1) Inquiry
CDCL185257 Human MAP3K3 ORF clone(NM_002401.3) Inquiry
CDCL185258 Mouse MAP3K3 ORF clone(NM_011947.3) Inquiry
CDCR373791 Rat Map3k3 ORF Clone(NM_001107058.2) Inquiry
CDCS410776 Human MAP3K3 ORF Clone (BC010464) Inquiry
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