Recombinant Human ACVR2A (C-Fc-6His)

Name: Recombinant Human ACVR2A (C-Fc-6His)
SKU: RP00311
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00311 Tag : C-Fc-6His

Expressed Region : Ala20-Pro134 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00311
Description	The Recombinant Human ACVR2A (C-Fc-6His) is produced in our Human Cell expression system. The amino acid region expressed is Ala20-Pro134 with a Fc-6His tag at the C terminus.
Species	Human
Tag	C-Fc-6His
Mol Weight	41.2 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Ala20-Pro134
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	ACVR2A
Synonyms	Activin Receptor Type-2A; Activin Receptor Type IIA; ACTR-IIA; ACTRIIA; ACVR2A; ACVR2

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This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

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