Recombinant Human ACVR2B (C-6His)

Name: Recombinant Human ACVR2B (C-6His)
SKU: RP00216
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00216 Tag : C-6His

Expressed Region : Ser19-Thr134 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00216
Description	The Recombinant Human ACVR2B (C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Ser19-Thr134 with a 6His tag at the C terminus.
Species	Human
Tag	C-6His
Mol Weight	14.37 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Ser19-Thr134
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	ACVR2B
Synonyms	Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B

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Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

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