Recombinant Cynomolgus IL-4RA (C-6His)

Name: Recombinant Cynomolgus IL-4RA (C-6His)
SKU: RP00328

Cat.No. : RP00328 Tag: C-6His

Expressed Region: Met26-Arg232 Expression System: Human Cell

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Product Details

Target Information

Cat. No.	RP00328
Description	The Recombinant Cynomolgus IL-4RA (C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Met26-Arg232 with a 6His tag at the C terminus.
Species	Cynomolgus
Tag	C-6His
Mol. Weight	24.6 KDa
Expressed Region	Met26-Arg232
Expression System	Human Cell
Format	Powder
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Conjugate	Unconjugated
Endotoxin Level	< 1 EU/µg of protein by LAL method
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	IL4RA
Background	This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Synonyms	Interleukin-4 receptor subunit alpha; IL-4R-alpha; CD124; IL4-BP; Soluble IL-4R-alpha

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