Recombinant Human ACVR2B (C-Fc-6His)

Name: Recombinant Human ACVR2B (C-Fc-6His)
SKU: RP00274

Cat.No. : RP00274 Tag: C-Fc-6His

Expressed Region: Ser19-Thr134 Expression System: Human Cell

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Product Details

Target Information

Cat. No.	RP00274
Description	The Recombinant Human ACVR2B (C-Fc-6His) is produced in our Human Cell expression system. The amino acid region expressed is Ser19-Thr134 with a Fc-6His tag at the C terminus.
Species	Human
Tag	C-Fc-6His
Mol. Weight	41.3 KDa
Expressed Region	Ser19-Thr134
Expression System	Human Cell
Format	Powder
Formulation	Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 10% Trehalose, 3% Mannitol, 0.05% Tween 80, 10 mM Methionine, pH8.5.
Conjugate	Unconjugated
Endotoxin Level	< 1 EU/µg of protein by LAL method
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	ACVR2B
Background	Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Synonyms	Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B

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