Human ERBB2 Stable Cell Line - CT26

The Human ERBB2 Stable CT26 Cell Line is a cellular model that is derived from the CT26 cell line, which is a mouse colon cancer cell line. The ERBB2 (ErbB-2) gene in this cell line has been stably integrated and overexpressed, allowing researchers to study the function and signaling of the ERBB2 protein. ERBB2 is a member of the ErbB family of receptor tyrosine kinases and is often amplified or overexpressed in human cancers, including breast cancer. The stable CT26 Cell Line is used to investigate the effects of inhibitors targeting ERBB2, which are potential novel therapies for patients with ERBB2-positive cancers. This cell line has been instrumental in the development of targeted treatments that could improve the outcomes for patients with these aggressive forms of cancer.The CT26 Cell Line is a mouse colorectal adenocarcinoma cell line that has been widely used in cancer research. It was established in 1985 from a tumor that was excised from a 12-month-old BALB/c mouse. Since then, the CT26 cell line has become a valuable tool for scientists studying the development, progression, and treatment of colorectal cancer.The CT26 cell line is characterized by its ability to grow rapidly in vitro, making it an ideal model for studying the biology of colorectal cancer. Additionally, the cells have been found to express a variety of molecules that are involved in the development of colorectal cancer, including tumor necrosis factor alpha, interleukin 6, and vascular endothelial growth factor.

The CT26 cell line has also been used in preclinical studies to test the efficacy of various anticancer agents, including chemotherapy drugs and immunotherapy agents. In recent years, researchers have been exploring the use of CT26 cells in combination with other models, such as organotypic culture models, to better understand the interactions between cancer cells and the surrounding microenvironment.