Rat Erbb2 ORF Clone(NM_017003.2)

Name: Rat Erbb2 ORF Clone(NM_017003.2)
SKU: CDCR378116
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR378116

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Product Information

Gene Information

Cat. No.	CDCR378116
Product Type	ORF Clone
Gene Abbr	Erbb2
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	3780 bp
Vector	pCMV6-Entry

Target Gene

ERBB2

Background

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

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