ODN 1720

Name: ODN 1720
SKU: CGON-16
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-16

Inquire for Price

Product Information

Cat. No.	CGON-16
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN 1720 can be used as a control for ODN 1688.
Features	• Classification: Type B control • Product format: Lyophilized product • Sequence: 5'-tccatgagcttcctgatgct-3' (lower case letters are phosphorothioate) • Specificity: Control for ODN 1688
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

Quick Inquiry

Q & A

Customer Reviews

Customer Q&As

What is the source of ODN 1720? Is it a natural product or synthetically made?

A: ODN 1720 is typically synthetically made through chemical synthesis methods.

What is the primary use of ODN 1720 in immunological research, and how does it impact the functionality of immune cells?

A: ODN 1720 is commonly used in immunological research to simulate immune responses and activate immune cells. It can influence the activity of immune cells, such as dendritic cell activation, and stimulate immune responses.

What is the primary application of ODN 1720 in immunological research, and how does it simulate immune responses?

A: ODN 1720 is commonly used in immunological research to simulate the immunostimulatory activity of CpG DNA. It simulates immune responses by activating the Toll-like receptor 9 (TLR9) pathway.

Does the synthesis process of ODN 1720 require special chemical reagents or equipment?

A: The synthesis of ODN 1720 typically requires the use of special deprotection reagents, nucleotide monomers, and equipment such as solid-phase synthesis columns to ensure the effectiveness and purity of synthesis.

How is the structure and sequence of ODN 1720 determined and verified?

A: The structure and sequence of ODN 1720 are usually determined and verified using techniques such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS) analysis, and DNA sequencing.

What are the stability and storage conditions of ODN 1720?

A: ODN 1720 should be stored under frozen conditions, typically at -20°C or lower temperatures, to ensure its stability and quality during long-term storage. Avoid frequent freeze-thaw cycles to minimize degradation.

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Question *

Name

Country *

Email *

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Product Name *

Catalog Name *

Rating

Needs improvement

Satisfaction

General satisfaction

Very satisfaction

Product Review Title *

Summary *