ODN 2395

Name: ODN 2395
SKU: CGON-17
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-17

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Product Information

Cat. No.	CGON-17
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN 2395 is a type C CpG ODN specific for human / murine TLR9.
Features	• Classification: Type C • Product format: Lyophilized product • Sequence: 5'-tcgtcgttttcggcgcgcgccg-3' (lower case letters are phosphorothioate) • Specificity: Human, Mouse, Rat
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

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Customer Q&As

Is ODN 2395 suitable for rats or other species?

A: ODN 2395 is suitable for use in Human, Mouse, Rat, and other species.

Is ODN 2395 a C-type CpG ODN?

A: ODN 2395 is a type C oligonucleotide.

Does ODN 2395 have a palindromic sequence?

A: ODN 2395 contains a partial palindrome sequence cggcgc:gcgccg.

What is the function of ODN 2395?

A: ODN 2395 can be used as a vaccine adjuvant and is also a TLR9 agonist.

How long can ODN 2395 be stored at -20°C?

A: ODN 2395 can be stored at -20°C for one year in powdered form and for six months at -80°C if in solution.

Can ODN 2395 be aliquoted for use?

A: Upon receipt, it can be aliquoted before use.

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