ODN M383

Name: ODN M383
SKU: CGON-22
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-22

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Product Information

Cat. No.	CGON-22
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN M383 can be used as a control for ODN M362.
Features	• Classification: Type C control • Product format: Lyophilized product • Sequence: 5'-tgctgctgcttgcaagcagcttgat-3' (lower case letters are phosphorothioate) • Specificity: Control for ODN M362
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

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What is the sequence of ODN M383?

A: 5'-tgctgctgcttgcaagcagcttgat-3

How should ODN M383 be dissolved?

A: Dissolve the total vial content in 122μl endotoxin-free water (included) or PBS.

How should ODN M383 be stored?

A: Store at 4°C in the dark.

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