ODN 2336

Name: ODN 2336
SKU: CGON-03
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-03

Inquire for Price

Product Information

Cat. No.	CGON-03
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN 2236 is a type A CpG ODN with a preference for human TLR9.
Features	• Classification: Type A • Product format: Lyophilized product • Sequence: 5'-gggGACGACGTCGTGgggggg-3' (lower case letters are phosphorothioate) • Specificity: Human, Mouse, Rat
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

Quick Inquiry

Q & A

Customer Reviews

Customer Q&As

What is the source of ODN 2336, including its production and purification processes?

A: ODN 2336 is typically produced using chemical synthesis methods, involving nucleotide synthesis techniques and specific protecting groups during the synthesis process. After synthesis, it undergoes multiple purification steps such as reverse-phase chromatography and ion-exchange chromatography to obtain high purity ODN 2336.

What is the chemical structure of ODN 2336, including its nucleotide sequence and modifications?

A: The chemical structure of ODN 2336 includes its nucleotide sequence and potential modifications. Its nucleotide sequence is typically a CpG oligodeoxynucleotide, consisting of a certain number of cytosine (C) and guanine (G) bases, along with possible phosphorylation modifications.

What biological process is ODN 2336 used for in cell lines, such as immune response or inflammation regulation?

A: ODN 2336 is commonly used for studying immune responses or inflammation regulation. It can mimic CpG DNA in the immune system, triggering responses in immune cells, such as dendritic cell activation, to promote immune reactions.

When using ODN 2336, how is its concentration and appropriate dosage determined to ensure experimental repeatability and accuracy?

A: Determining the concentration and appropriate dosage of ODN 2336 typically involves initial experiments and optimization. This includes conducting experiments at different concentrations to find the optimal dosage and using specific experimental measurement methods to accurately determine the concentration of ODN 2336.

Is there selectivity of ODN 2336 for different types of cell lines, and how might this selectivity impact research?

A: ODN 2336 may exhibit selectivity for different types of cell lines. This selectivity can impact the interpretation and application of research results. Therefore, cell-line-specific experiments are needed to understand its effects.

What are the potential clinical applications of ODN 2336, and are there known side effects or safety concerns?

A: ODN 2336 may have potential clinical applications, such as in immunotherapy. However, further clinical research is needed to assess its safety and potential side effects. Known side effects may include immune-related adverse reactions, but specifics require further investigation.

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Question *

Name

Country *

Email *

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Product Name *

Catalog Name *

Rating

Needs improvement

Satisfaction

General satisfaction

Very satisfaction

Product Review Title *

Summary *