Human FAP Stable Cell Line - KB

The transmembrane protein Fibroblast Activation Protein (FAP), a member of the dipeptidyl peptidase family, is expressed in the human FAP stable cell line KB via engineering. The FAP gene spans genomic coordinates from 162,170,684 to 162,243,445 (GRCh38) and is situated on chromosome 2q24.2. The FAP gene's open reading frame spans about 1800 base pairs and codes for a 619-amino acid protein. One DSL domain, one intracellular domain, and six domains resembling epidermal growth factor make up its entire structure.Among members of the FAP family, the DSL domain at the extracellular domain's N-terminus is highly conserved and necessary for binding to particular substrates. Since the intracellular domain of FAP is so brief, its precise purpose is still unknown. Research has shown that FAP is biasedly expressed in a number of tissues, including the gall bladder (RPKM 5.1), the endometrium (RPKM 7.5), and eleven additional tissues.

An oral cancer provided the human epithelial cell line known as KB cells. They can be grown in vitro using conventional cell culture methods and display adherent growth properties. These cells' genetic stability and ease of care make them popular for use in cancer research.