Mouse Fap Stable Cell Line - NIH/3T3

Mouse Fap refers to the Fap gene present in mice. FAP (Fibroblast Activating Protein) is a serine protease used in a variety of biological functions and processes. FAP is commonly overexpressed during wound healing, tissue remodeling, inflammation, and fibrosis. However, it is best known for being highly expressed in more than 90% of epithelial cancers, including breast, colorectal, pancreatic, lung, and ovarian cancers, and is found exclusively in the tumor stroma. The unique expression pattern of FAP is primarily restricted to the tumor stroma in adults, making it an attractive target for novel cancer therapies. It is speculated that FAP exerts tumor-promoting effects by remodeling the extracellular matrix, promoting tumor growth, enhancing angiogenesis, and inhibiting anti-tumor immune responses. NIH_3T3 fibroblasts derived from mouse embryonic tissue. Their ability to continuously grow and multiply makes them ideal for creating large numbers of cells. The mouse Fap stable cell line – NIH_3T3 will be valuable to researchers interested in studying cancer, specifically the role of stromal cells and the function of fibroblast activating protein in tumor development. They can also be used to develop and test potential cancer treatments and explore the molecular pathways involved in tumor growth.