Human ACE2 Stable Cell Line - HEK293

Name: Human ACE2 Stable Cell Line - HEK293
SKU: CSC-RO0292

Cat.No. : CSC-RO0292 Host Cell: HEK293

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Cat. No.	CSC-RO0292
Description	This cell line is engineered to stably overexpressing human angiotensin I converting enzyme 2 (ACE2). HEK 293 is a human embryonic kidney cell line which has been widely used in cell biology research. HEK293-human ACE2 cell line is a powerful tool for in vitro screening and characterization of potential drugs against SARS-CoV, SARS-Cov2 (2019-nCoV).
Gene	ACE2
Gene Species	Homo sapiens (Human)
Host Cell	HEK293
Host Cell Species	Homo sapiens (Human)
Stability	Validated for at least 10 passages
Application	1. Study the mechanisms of viral entry and replication 2. Research and in vitro screening of potential drugs 3. Vaccine development 4. The production of pseudotyped viruses
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Media Type	Cells were cultured in DMEM supplemented with 10% fetal bovine serum.
Growth Properties	Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO₂. Split at 80-90% confluence, approximately 1:3-1:6.
Freeze Medium	Complete medium supplemented with 10% (v/v) DMSO
Shipping	Dry ice
Storage	Liquid nitrogen

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

CSC-RO0292-Human ACE2 Stable Cell Line - HEK293-DataSheet

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The Human ACE2 (Angiotensin-Converting Enzyme 2) gene encodes a membrane-bound protein that acts as a carboxypeptidase, playing a key role in the regulation of the renin-angiotensin-aldosterone system. ACE2 is involved in the conversion of angiotensin II to angiotensin 1-7, which has vasodilatory effects and is protective against cardiovascular diseases. However, ACE2 is also the receptor for the SARS-CoV-2 virus, making it central to the pathogenesis of COVID-19.

The HEK293 cell line has been modified to stably express the Human ACE2 gene. This stable cell line provides a valuable tool for studying the physiological functions of ACE2 and its role in the pathogenesis of COVID-19. Researchers can use this cell line to investigate the interaction of ACE2 with SARS-CoV-2, its role in viral entry and replication, and the development of potential therapeutic strategies to target the ACE2 pathway.

The Human ACE2 Stable Cell Line - HEK293 is a cell line that expresses the ACE2 gene, which encodes for angiotensin-converting enzyme 2. This enzyme plays a crucial role in the renin-angiotensin-aldosterone system and has been identified as the receptor for SARS-CoV-2, the virus responsible for COVID-19. The applications of this cell line are:

Viral Entry Mechanisms: This cell line is invaluable for studying the interaction between ACE2 and SARS-CoV-2, providing insights into the viral entry process and the development of antiviral strategies.

Drug Screening: Researchers can use the Human ACE2 Stable Cell Line to screen for compounds that inhibit the interaction between ACE2 and SARS-CoV-2, potentially leading to the discovery of new antiviral drugs.

Cardiovascular Research: ACE2 is also involved in the regulation of blood pressure and heart function. This cell line can be used to study the role of ACE2 in cardiovascular diseases and to develop treatments for conditions such as hypertension and heart failure.

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