Residual DNA Quantification Kit- CHO

Chinese Hamster Ovary (CHO) cells are a cell line that were originally isolated from the ovaries of the Chinese hamster Cricetulus griseus in the 1950s. CHO cells are particularly well suited for the production of recombinant proteins and therapeutic antibodies. Their eukaryotic nature enables them to properly fold and post-translationally modify complex proteins, which is critical for the production of biologically active and effective therapeutics. CHO cells have been extensively optimized and various isoforms and derivatives have been created, such as CHO-K1, CHO-S, and DG44, each with unique properties that benefit different research and production purposes.

While CHO cells have provided significant advances and benefits, their use has raised concerns, particularly regarding the presence of residual host cell DNA in the final product. High levels of residual DNA can pose potential risks, including carcinogenicity and immunogenicity. Regulatory agencies around the world, including the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), have established strict guidelines regarding acceptable levels of residual DNA. Therefore, ensuring that DNA is removed or reduced to acceptable levels is critical to the production of safe biopharmaceuticals. The Residual DNA Quantification Kit - CHO is specifically designed to meet the need for accurate, sensitive, and reliable quantification of residual DNA in CHO cells.