Residual DNA Size Analysis Kit-BHK

During the manufacturing of biopharmaceutical products, downstream processing steps are designed not only to purify the desired biomolecule, but also to remove impurities, including residual host cell DNA. Residual host cell DNA in the final product presents potential risks, including carcinogenicity and immunogenicity. Therefore, regulatory guidelines require strict monitoring of the amount and size of residual DNA in biologics.

BHK cells, or baby hamster kidney cells, are a cell line derived from the kidneys of baby Syrian hamsters. These cells were first isolated and cultured in the early 1960s and have since become a valuable resource for biomedical research and biotechnology. BHK cells are a cell line widely used to produce veterinary vaccines and other biologics. These cells were chosen because they can grow in both adherent and suspension cultures, have high transfection efficiency, and have a fast growth rate, making them suitable for large-scale bioproduction. Despite these advantages, it is important to ensure that any residual DNA in BHK cells is minimized and characterized. The Residual DNA Size Analysis Kit - BHK is specifically designed to detect and measure the size distribution of residual DNA in BHK cell-derived products. The size analysis capability adds another layer of safety assessment by providing information on whether the residual DNA is in a potentially problematic size range that might integrate into the host genome.