Panoply™ Human TNFRSF1B Over-expressing Stable Cell Line

Name: Panoply™ Human TNFRSF1B Over-expressing Stable Cell Line
SKU: CSC-SC016364
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-SC016364

Host Cell : HEK293 (CHO and other cell types are also available) Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

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Gene Information

Cat. No.	CSC-SC016364
Description	Using Creative Biogene's proprietary lentiviral vectors, we subclone the target gene into lentivector, generate the lentivirus particles, sequentially infect the cell line HEK293 (other cell types are also available according to your requirements), and select the clones constantly expressing target gene at high level.
Target Gene	TNFRSF1B
Gene Species	Homo sapiens (Human)
Host Cell	HEK293 (CHO and other cell types are also available)
Host Cell Species	Species varies
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Disease research
Size	2 × 10^6 cells / vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry Ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [ Homo sapiens ]
Gene Symbol	TNFRSF1B
Synonyms	p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II
Gene Description	tumor necrosis factor receptor superfamily, member 1B
GeneID	7133
Uni ProtID	P20333
mRNA Refseq	NM_001066.2
Protein Refseq	NP_001057.1
Chromosome Location	1p36.22
Function	protein binding; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding;
Pathway	Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis Modulation and Signaling, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;
MIM	191191

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Disease development is often driven by multiple factors. While angiogenesis-related genes (ARGs) have been implicated in cancer, their role in colon cancer remains understudied. Here, researchers aimed to explore potential ARG-based biomarkers to improve prognosis and treatment outcomes for patients with colon cancer. They conducted the first comprehensive analysis of the prognostic value of ARGs in colon cancer and identified three ARGs with prognostic value. A prognostic risk model was constructed based on these three ARGs and validated in an independent external colon cancer dataset. Results demonstrated that this prognostic signature was an independent risk factor for colon cancer and significantly correlated with clinical features of patients. Furthermore, this signature was closely associated with the immune microenvironment of colon cancer. Cell-based experiments demonstrated that high expression of TNF receptor superfamily member 1B (TNFRSF1B) significantly promoted apoptosis and inhibited proliferation in colon cancer cells. Therefore, TNFRSF1B may be a key regulator of colon cancer progression by regulating its intracellular functions.

The results of cell apoptosis showed that compared with the control group cells, the colon cancer apoptosis rate of the TNFRSF1B-overexpressing HTC116 colon cancer cells were significantly increased (Figure 1A-B).

Figure 1. Colon cancer apoptosis experiment. (Liu F, et al., 2025)

Cell cycle analysis results showed that compared with the control group cells, the TNFRSF1B-overexpressing cells showed significant inhibition of colon cancer cells in the G1 phase (Figure 2A-B).

Figure 2. Colon cancer cell cycle experiment. (Liu F, et al., 2025)

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