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Cat.No. : CSC-SC016364 Host Cell: HEK293 (CHO and other cell types are also available)
| Cat. No. | CSC-SC016364 |
| Description | Using Creative Biogene's proprietary lentiviral vectors, we subclone the target gene into lentivector, generate the lentivirus particles, sequentially infect the cell line HEK293 (other cell types are also available according to your requirements), and select the clones constantly expressing target gene at high level. |
| Gene | TNFRSF1B |
| Gene Species | Homo sapiens (Human) |
| Host Cell | HEK293 (CHO and other cell types are also available) |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Disease research |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Size Form | 2 × 10^6 cells / vial |
| Shipping | Dry Ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
Disease development is often driven by multiple factors. While angiogenesis-related genes (ARGs) have been implicated in cancer, their role in colon cancer remains understudied. Here, researchers aimed to explore potential ARG-based biomarkers to improve prognosis and treatment outcomes for patients with colon cancer. They conducted the first comprehensive analysis of the prognostic value of ARGs in colon cancer and identified three ARGs with prognostic value. A prognostic risk model was constructed based on these three ARGs and validated in an independent external colon cancer dataset. Results demonstrated that this prognostic signature was an independent risk factor for colon cancer and significantly correlated with clinical features of patients. Furthermore, this signature was closely associated with the immune microenvironment of colon cancer. Cell-based experiments demonstrated that high expression of TNF receptor superfamily member 1B (TNFRSF1B) significantly promoted apoptosis and inhibited proliferation in colon cancer cells. Therefore, TNFRSF1B may be a key regulator of colon cancer progression by regulating its intracellular functions.
The results of cell apoptosis showed that compared with the control group cells, the colon cancer apoptosis rate of the TNFRSF1B-overexpressing HTC116 colon cancer cells were significantly increased (Figure 1A-B).
Figure 1. Colon cancer apoptosis experiment. (Liu F, et al., 2025)
Cell cycle analysis results showed that compared with the control group cells, the TNFRSF1B-overexpressing cells showed significant inhibition of colon cancer cells in the G1 phase (Figure 2A-B).
Figure 2. Colon cancer cell cycle experiment. (Liu F, et al., 2025)
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