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Cat.No. : CSC-RO1059 Host Cell: Jurkat
| Cat. No. | CSC-RO1059 |
| Description | Jurkat-TNFRSF1B cell line is engineered to stably overexpress human TNFRSF1B. |
| Gene | TNFRSF1B |
| Gene Species | Homo sapiens (Human) |
| Host Cell | Jurkat |
| Host Cell Species | Homo sapiens (Human) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human TNFRSF1B Stable Cell Line-Jurkat originated from the Jurkat cell line, which is a well-established human T lymphocyte cell line. The stable cell line was developed by introducing and maintaining a stable expression of the TNFRSF1B gene in Jurkat cells through genetic modification techniques. This modification allows the cells to express the TNFRSF1B receptor on their surface consistently.
A: The Human TNFRSF1B Stable Cell Line-Jurkat is primarily used in research related to the tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and its signaling pathways. Common applications include studying apoptosis, immune responses, and inflammation regulation. Additionally, it can be utilized in drug screening and development studies targeting TNFRSF1B.
A: To maintain the stability of the Human TNFRSF1B Stable Cell Line-Jurkat, researchers should culture the cells under appropriate conditions. This includes maintaining the expression of TNFRSF1B by supplementing the culture medium with selection markers like antibiotics or other selection agents. Regular monitoring of the cell line's phenotype and gene expression is crucial to ensure stability over time.
A: Researchers commonly investigate the signaling pathways associated with TNFRSF1B, such as the NF-κB pathway, MAPK pathway, and JAK-STAT pathway, using the Human TNFRSF1B Stable Cell Line-Jurkat. Downstream effects of TNFRSF1B activation, including cytokine production, cell proliferation, and apoptosis, are also studied to understand the receptor's role in immune and inflammatory responses.
A: Yes, when working with the Human TNFRSF1B Stable Cell Line-Jurkat, researchers need to consider the potential effects of TNFRSF1B overexpression on cell behavior and signaling. It's essential to carefully design experiments and controls to account for these changes. Additionally, maintaining stable expression of TNFRSF1B may require ongoing selection pressure to prevent loss of expression.
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