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Human TLR2 Stable Cell Line-HEK293

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Cat.No.
CSC-RO0054
Cell Line Description
This cell line is a stably transfected cell line which expresses human Toll-like receptor 2 (TLR2) with an N-terminal HA tag.
Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases.
Host Cell
HEK293
Ship
Dry ice
Antigen Gene Information
Official Symbol
TLR2
Synonyms
TIL4; CD282
GeneID
UniProt ID
O60603
Chromosome Location
4q31.3

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