Rat Tlr2 ORF Clone(NM_198769.2)

Name: Rat Tlr2 ORF Clone(NM_198769.2)
SKU: CDCR382224
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR382224

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Product Information

Gene Information

Cat. No.	CDCR382224
Product Type	ORF Clone
Gene Abbr	Tlr2
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	2355 bp
Vector	pCMV6-Entry

Target Gene

TLR2

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021]

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